Analysis of cell motility system with EMT in tumor invasion and metastasis of oral cancer
Analysis of cell motility system with EMT in tumor invasion and metastasis of oral cancer
批准号:
21592554
负责人:
SHIMASUE Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Snail, a transcription factor and EMT inducer, enable squamous cell carcinoma(SCC) cells to acquire high-invasiveness. Cyr61 is a humoral factor which known to be a angiogenesis factor and a target of which its transcription increases by Snail. Forced expression of Cyr61 in SCC cells directed their high-invasiveness and stimulation of recombinant Cyr61 gained their motility through activation of Rho. These data indicates that both of autocrine and paracrine Cyr61 offers crucial roles for the establishment of local invasion of SCC.
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口腔扁平上皮癌における高度浸潤能獲得機構の解析
口腔鳞癌高级侵袭能力获得机制分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[田中扶美, 他]
通讯作者:
他
PGE(2) targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 induction
PGE(2) 以激活的表皮生长因子受体家族为目标,通过 NR4A2 诱导,针对 5-氟尿嘧啶存活的鳞状细胞癌细胞
DOI:
--
发表时间:
2011
期刊:
Cancer Lett
影响因子:
9.7
作者:
[Yuji Kawai, Yukie Nagai, Minoru Asada, Nguyen PT, ○Yoshio Okahata and Hiroyuki Furusawa, Shigeishi H]
通讯作者:
Shigeishi H
口腔扁平上皮癌の抗癌剤耐性獲得機構における微小環境因子の関与
微环境因素参与口腔鳞癌抗癌耐药获得机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H, 熊谷泉, 東川晃一郎]
通讯作者:
東川晃一郎
DOI:
10.3892/ijo_00000286
发表时间:
2009-06-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Shigeishi, Hideo, Fujimoto, Shinichi, Kamata, Nobuyuki]
通讯作者:
Kamata, Nobuyuki
Lymphangiogenesis and metastasis : Role of tumor-inducedlymphatic vessel activation in extramammary Paget' s disease
淋巴管生成和转移:肿瘤诱导的淋巴管激活在乳房外佩吉特病中的作用
DOI:
--
发表时间:
2009
期刊:
Am JPathol
影响因子:
--
作者:
[Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K]
通讯作者:
Hashimoto K
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