Role of functionallipids in cardiovascular homeostasis and diseases
Role of functionallipids in cardiovascular homeostasis and diseases
批准号:
21390057
负责人:
TAKUWA Yoh
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The lysophospholipid mediator sphingosine-1-phosphate(S1P) exerts a facilitative effect on atherosclerosis via S1P2 receptor in macrophages, regulatory effects on angiogenesis including tumor angiogenesis via multiple receptors, and modulatory effects on vascular barrier function. S1P also is involved in cardiac remodeling. Phosphatidylinositol 3-kinase class II, which produces phosphatidylinositol 3-phosphate, plays the crucial role in angiogenesis through a novel mechanism. These observations suggest the possibility that the functional lipids S1P and phosphatidylinositol 3-phosphate could be potential novel therapeutic targets for cardiovascular diseases.
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クラスII型PI3キナーゼC2αの血管形成における生理的役割:コンディショナルKOマウスを用いた解析
II 类 PI3 激酶 C2α 在血管生成中的生理作用:使用条件 KO 小鼠进行分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[吉岡和晃, 吉田耕太朗, 安藝翔, Kuntal Biswas, Wa Du, Xun Qi, Fei Wang, 多久和典子, 岡本安雄, 多久和陽]
通讯作者:
多久和陽
生体におけるスフィンゴシン-1-リン酸シグナル系の機能
1-磷酸鞘氨醇信号系统在生物体内的功能
DOI:
--
发表时间:
2009
期刊:
実験医学 27(13)
影响因子:
--
作者:
[多久和陽, 岡本安雄, 杜娃, 戚〓, 吉岡和晃, 多久和典子]
通讯作者:
多久和典子
Involvement of sphingosine-1-phosphate and S1P(1) in angiogenesis : Analyses using a new S1P(1) antagonist of non-sphingosine-1-phosphate analog
1-磷酸鞘氨醇和 S1P(1) 参与血管生成:使用非 1-磷酸鞘氨醇类似物的新型 S1P(1) 拮抗剂进行分析
DOI:
--
发表时间:
2009
期刊:
Biochem Pharmacol (in press)
影响因子:
--
作者:
[多久和陽, 岡本安雄, 杜娃, 戚〓, 吉岡和晃, 多久和典子, K.Sugimoto, H.Zhong, H Ohkawara, 多久和陽, Y. Takuwa, A. Shiratsuchi, K. Yonesu]
通讯作者:
K. Yonesu
腫瘍血管新生におけるスフィンゴシンー1-リン酸受容体S1P2の役割
1-磷酸鞘氨醇受体S1P2在肿瘤血管生成中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[多久和典子, 杉本直俊, 多久和陽, S.Nagasawa et al., T.Senokuchi et al., M.Philippova et al., H.Ohkawara et al., 多久和 典子 他, N.Sugimoto et al., 多久和陽, 多久和陽, Wa Du]
通讯作者:
Wa Du
DOI:
10.1016/j.ejphar.2010.02.038
发表时间:
2010-05-25
期刊:
EUROPEAN JOURNAL OF PHARMACOLOGY
影响因子:
5
作者:
[Qi, Xun, Okamoto, Yasuo, Takuwa, Yoh]
通讯作者:
Takuwa, Yoh
共 56 条
Control of vascular barrier integrity by MTM family of phosphatidylinositol 3-phosphate phosphatase
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批准号:25670162
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:TAKUWA Yoh
-
依托单位:
Mechanisms for the regulation of vascular homeostasis by functional lipid molecules
-
批准号:24390051
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
-
财政年份:2012
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负责人:TAKUWA Yoh
-
依托单位:
Disruption of vascular integrity by deficiency of PI3K class II αisoform in mice
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批准号:23659170
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2011
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负责人:TAKUWA Yoh
-
依托单位:
Signaling for regulating hematogenous metastasis of tumors
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批准号:17014034
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$29.95万
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财政年份:2005
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负责人:TAKUWA Yoh
-
依托单位:
Molecular biological analysis of the lipid morphogen sphingosine-1-phosphate
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批准号:13470008
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
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财政年份:2001
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负责人:TAKUWA Yoh
-
依托单位:
Molecular biological research of biological functions of the sphingoshine-1-phosphate receptors
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批准号:11470014
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.96万
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财政年份:1999
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负责人:TAKUWA Yoh
-
依托单位:
Molecular mechanisms for local regulation of vascular tonics
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批准号:07457009
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.65万
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财政年份:1995
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负责人:TAKUWA Yoh
-
依托单位:
Molecular Characterization of Purinergic Receptor and its Signal Transduction in the Vascular System
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批准号:04670045
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1992
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负责人:TAKUWA Yoh
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依托单位:
海外基金