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Analysis of infection mechanisms of hepatitis C virus and establishment of the indicator cell lines for viral infection

Analysis of infection mechanisms of hepatitis C virus and establishment of the indicator cell lines for viral infection
丙型肝炎病毒感染机制分析及病毒感染指示细胞系的建立
批准号:
21390138
负责人:
MATSUURA Yoshiharu
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
A liver-specific microRNA, miR-122, has been shown to participate in the efficient replication of hepatitis C virus(HCV). In this study, we examined the possibility of establishing a new permissive cell line for HCV propagation by the expression of miR-122. Among the cell lines we examined, Hep3B cells stably expressing miR-122(Hep3B/ miR-122) exhibited a significant enhancement of HCVcc propagation. Furthermore, a line of" cured" cells established by elimination of HCV RNA from the Hep3B/ miR-122 replicon cells exhibited an enhanced expression of miR-122.
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会议论文
Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms : a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28-Dependent Mechanism.
丙型肝炎病毒核心蛋白的蛋白酶体周转由两种不同的机制调节:泛素依赖性机制和不依赖泛素但 PA28 依赖性机制。
DOI: --
发表时间: 2009
期刊: J.Virol. 83
影响因子: --
作者: [Kojima, T., Suzuki R.]
通讯作者: Suzuki R.
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [田鍬修平, 寒原裕登, 藤田尚信, 野田健司, 森石恆司, 吉森保, 松浦善治]
通讯作者: 松浦善治
Acquisition of complement resistance through incorporation of CD55/DAF into viral particles bearing baculovirus GP64.
通过将 CD55/DAF 掺入携带杆状病毒 GP64 的病毒颗粒中获得补体抗性。
DOI: --
发表时间: 2010
期刊: J.Vrol.
影响因子: --
作者: [Yoshida R, et al, Kaname Y.]
通讯作者: Kaname Y.
C型肝炎ウイルスの増殖と病原性発現に関与する宿主因子~細胞内蛋白質分解システムの関与について~
参与丙型肝炎病毒增殖和致病性的宿主因素 - 细胞内蛋白水解系统的参与 -
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Sato K, Misawa N, Nie C, Rei Takahashi R, Ito M, Kuzushima K, Takada K, Koyanagi Y, 松浦善治]
通讯作者: 松浦善治
71
    Significance of interaction between SPP and HCV core protein on viral life cycle.
    • 批准号:
      19H03479
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.07万
    • 财政年份:
      2019
    • 负责人:
      MATSUURA Yoshiharu
    • 依托单位:
    Analysis of propagation mechanisms of hepatitis C virus and establishment of novel permissive cell lines
    • 批准号:
      24390113
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.98万
    • 财政年份:
      2012
    • 负责人:
      MATSUURA Yoshiharu
    • 依托单位:
    Establishing the foundations of comparative law by developing a database of legal information in Japan, Korea, Taiwan and China.
    • 批准号:
      20240024
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $32.36万
    • 财政年份:
      2008
    • 负责人:
      MATSUURA Yoshiharu
    • 依托单位:
    Analysis of host factors involved in the infection and replication of hepatitis C virus
    • 批准号:
      19390133
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.06万
    • 财政年份:
      2007
    • 负责人:
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    • 依托单位:
    海外基金