Analysis of infection mechanisms of hepatitis C virus and establishment of the indicator cell lines for viral infection
Analysis of infection mechanisms of hepatitis C virus and establishment of the indicator cell lines for viral infection
批准号:
21390138
负责人:
MATSUURA Yoshiharu
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
A liver-specific microRNA, miR-122, has been shown to participate in the efficient replication of hepatitis C virus(HCV). In this study, we examined the possibility of establishing a new permissive cell line for HCV propagation by the expression of miR-122. Among the cell lines we examined, Hep3B cells stably expressing miR-122(Hep3B/ miR-122) exhibited a significant enhancement of HCVcc propagation. Furthermore, a line of" cured" cells established by elimination of HCV RNA from the Hep3B/ miR-122 replicon cells exhibited an enhanced expression of miR-122.
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Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms : a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28-Dependent Mechanism.
丙型肝炎病毒核心蛋白的蛋白酶体周转由两种不同的机制调节:泛素依赖性机制和不依赖泛素但 PA28 依赖性机制。
DOI:
--
发表时间:
2009
期刊:
J.Virol. 83
影响因子:
--
作者:
[Kojima, T., Suzuki R.]
通讯作者:
Suzuki R.
C型肝炎ウイルスの感染におけるオートファジーの意義
自噬在丙型肝炎病毒感染中的意义
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[田鍬修平, 寒原裕登, 藤田尚信, 野田健司, 森石恆司, 吉森保, 松浦善治]
通讯作者:
松浦善治
Acquisition of complement resistance through incorporation of CD55/DAF into viral particles bearing baculovirus GP64.
通过将 CD55/DAF 掺入携带杆状病毒 GP64 的病毒颗粒中获得补体抗性。
DOI:
--
发表时间:
2010
期刊:
J.Vrol.
影响因子:
--
作者:
[Yoshida R, et al, Kaname Y.]
通讯作者:
Kaname Y.
C型肝炎ウイルスの増殖と病原性発現に関与する宿主因子~細胞内蛋白質分解システムの関与について~
参与丙型肝炎病毒增殖和致病性的宿主因素 - 细胞内蛋白水解系统的参与 -
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sato K, Misawa N, Nie C, Rei Takahashi R, Ito M, Kuzushima K, Takada K, Koyanagi Y, 松浦善治]
通讯作者:
松浦善治
A splice variant of CD44 participates in the IP-10 production in cells infected with HCV
CD44 的剪接变体参与 HCV 感染细胞中 IP-10 的产生
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Takayuki Abe, Kohji Moriishi, and Yoshiharu Matsuura]
通讯作者:
and Yoshiharu Matsuura
共 71 条
Significance of interaction between SPP and HCV core protein on viral life cycle.
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批准号:19H03479
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.07万
-
财政年份:2019
-
负责人:MATSUURA Yoshiharu
-
依托单位:
Analysis of propagation mechanisms of hepatitis C virus and establishment of novel permissive cell lines
-
批准号:24390113
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2012
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负责人:MATSUURA Yoshiharu
-
依托单位:
Establishing the foundations of comparative law by developing a database of legal information in Japan, Korea, Taiwan and China.
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批准号:20240024
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.36万
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财政年份:2008
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负责人:MATSUURA Yoshiharu
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依托单位:
Analysis of host factors involved in the infection and replication of hepatitis C virus
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批准号:19390133
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2007
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负责人:MATSUURA Yoshiharu
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依托单位:
Study on molecular mechanisms of hepatitis C virus infection.
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批准号:16017252
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$9.6万
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财政年份:2004
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负责人:MATSUURA Yoshiharu
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依托单位:
Study on infection and maturation mechanisms of hepatitis C virus and its host response.
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批准号:15209017
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.37万
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财政年份:2003
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负责人:MATSUURA Yoshiharu
-
依托单位:
Professional Legal Education under the Environment of Computer Networks : Development of A Disinterested & Participatory Review System of Professional Skills Training
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批准号:14GS0115
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项目类别:Grant-in-Aid for Creative Scientific Research
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资助金额:$274.48万
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财政年份:2002
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负责人:MATSUURA Yoshiharu
-
依托单位:
Theoretical Research on Evaluation and Methods for Legal Assistance Activities
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批准号:13123204
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$49.66万
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财政年份:2001
-
负责人:MATSUURA Yoshiharu
-
依托单位:
Study on infection mechanisms of hepatitis C virus
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批准号:12470072
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.58万
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财政年份:2000
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负责人:MATSUURA Yoshiharu
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依托单位:
Study on maturation and replication mechanisms of Pestivirus and hepatitis C virus
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批准号:07456137
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.1万
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财政年份:1995
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负责人:MATSUURA Yoshiharu
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依托单位:
Development of Computer Assisted Legal Study and Legal Education and Accumulation of a Relevant Data-base for Effective Lawyering
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批准号:63520020
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.02万
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财政年份:1988
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负责人:MATSUURA Yoshiharu
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依托单位:
海外基金