Aiming at a new development of the postmortem diagnosis of the drug-related cadaver : Investigation of genetic background

药物相关性横纹肌溶解症可能由遗传背景引起。我们分析了潜在的横纹肌溶解症的易感基因在尸检的药物中毒，如甲基苯丙胺的情况下。发现了一些突变，然后，使用算法分析，几个突变被认为是潜在的影响蛋白质功能。这些结果揭示了横纹肌溶解症的发病可能与横纹肌溶解症易感基因的突变和甲基苯丙胺的浓度或甲基苯丙胺引起的体温过高有关。需要更多的横纹肌溶解症尸检病例，对其他横纹肌溶解症易感基因的研究有助于明确横纹肌溶解症与遗传背景之间的关系。

There is a possibility that rhabdomyolysis related to drug can be caused by genetic background. We analyzed potential rhabdomyolysis-susceptibility genes in autopsy cases of drug poisoning such as methamphetamine. Some mutations were found, then, using algorithms analysis, several mutation were considered potentially to impact on protein function. These results reveal the possibility that the onset of rhabdomyolysis is associated with both the mutation in the rhabdomyolysis-susceptibility gene and the concentration of methamphetamine or the hyperthermia induced by methamphetamine. A lot more autopsy cases of rhabdomyolysis were required and investigation of other rhabdomyolysis-susceptibility genes helps to clear association between rhabdomyolysis and genetic background.