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Identification of the responsible gene(s) for congenital heart defect in Down syndrome.

Identification of the responsible gene(s) for congenital heart defect in Down syndrome.
鉴定唐氏综合症先天性心脏病的相关基因。
批准号：
21791007
负责人：
MIYAMOTO Ken-ichi
金额：
$2.75万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791007/
关键词：
ダウン症心奇形ノックアウトマウスZfp295zinc finger protein 295DS-CHD MCRダウン症モデルマウスヒト21番染色体マウス16番染色体tryptophan rich basic protein

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中文摘要
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英文摘要
Down syndrome (DS) is the most common genetic disease caused by chromosomal aneuploidy, and variable symptoms including the mental retardation and the characteristic face are observed in patients with DS. However, the responsible genes for the incidences of each symptom and their molecular mechanisms have not been cleared. In this study, we focused on the congenital heart defect that is observed with relatively high frequency in DS, and tried to generate the knockout mice of Zfp295 that is one of the candidate genes for Down syndrome congenital heart defect (DS-CHD) to elucidate the molecular pathogenesis of DS-CHD.
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