Role of ESCRT proteins in the malignant phenotype control of Head and Neck Cancer Cells

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Head and Neck Cancer (HNC) originates from the pharynx, and larynx. Improvement in the management, as well as targeted therapy, is required to maintain patients' quality of life and survival. In this study, we investigated how HNC which is linked to EMT is regulated by the ESCRT vesicular transport system. Forced expression of the dominant negative ESCRT regulator, the dominant negative VPS4, in HNC cell lines reduced the cancer stemness phenotype, such as ALDH1 activity. In contrast, cell morphology and motility was not altered. Our results suggest that ESCRT system may control the malignant phenotypes of HNC.