Cytokine Immuno-gene Therapy Against Head and Neck Squamous Cell Carcinoma
Cytokine Immuno-gene Therapy Against Head and Neck Squamous Cell Carcinoma
批准号:
21791632
负责人:
NAKANO Hiroshi
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
我们已经证明IL-21和IL-27抑制SCCVII肿瘤生长(J。基因医学2006)。2010年,我们研究了IL-27基因转移引发抗肿瘤免疫的机制。结果表明,IL-27基因转染增强了NK细胞的细胞毒活性。此外,我们还证实了CDDP电化疗可增强IL-21或IL-27基因转移的抗肿瘤作用。2011年,我们报道了IL-28与CDDP协同作用抑制SCCVII的生长(J。immunother 2011)。
英文摘要
We have demonstrated that IL-21 and IL-27 suppress SCCVII tumor growth(J. Gene Med 2006).In 2010, we investigated the mechanisms of antitumor immunity elicited by IL-27 gene transfer. The results shows that IL-27 gene transfer augmented cytotoxic activity of NK cells.Furthermore, we demonstrated antitumor effect induced be IL-21 or IL-27 gene transfer was enhanced by electrochemotherapy with CDDP.In 2011, we have reported that IL-28 acts synergistically with CDDP to suppress the growth of SCCVII(J. immunother 2011).
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当科における進行舌癌の臨床的検討.
我科晚期舌癌临床回顾。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[島田剛敏, 他]
通讯作者:
他
顎下腺癌治療における術後放射線治療に関する検討.
考虑术后放疗治疗颌下腺癌。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[島田剛敏, 他]
通讯作者:
他
当科における耳下腺癌の症例の検討.
我们科室腮腺癌病例回顾。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[中井茂, 他]
通讯作者:
他
当科におけるT3・4中咽頭側壁癌症例の検討.
我科T3/4口咽侧壁癌病例回顾。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[中野宏, 他]
通讯作者:
他
DOI:
10.1097/cji.0b013e318204ed70
发表时间:
2011-03
期刊:
Journal of Immunotherapy
影响因子:
3.9
作者:
[Koichiro Yoshimoto;T. Kishida;H. Nakano;M. Matsui;M. Shin-Ya;Taketoshi Shimada;S. Nakai;J. Imanishi;M. Takeuchi;Y. Hisa;O. Mazda]
通讯作者:
Koichiro Yoshimoto;T. Kishida;H. Nakano;M. Matsui;M. Shin-Ya;Taketoshi Shimada;S. Nakai;J. Imanishi;M. Takeuchi;Y. Hisa;O. Mazda
共 13 条
Empirical study for bringing up ability to solve a problem by applying a having learned matter
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批准号:22500798
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2010
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负责人:NAKANO Hiroshi
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依托单位:
Proteomics analysis of a mechanism of sinusoidal endothelial cell injury after receiving oxaliplatin-based chemotherapy in colorectal liver metastases.
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批准号:22591509
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2010
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负责人:NAKANO Hiroshi
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依托单位:
Development of a Context-aware Authoring Tool for Simulation Learning Materials
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批准号:21500946
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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负责人:NAKANO Hiroshi
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依托单位:
The molecular mechanisms of chronic exercise to improve the developmental disorders
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批准号:21500642
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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负责人:NAKANO Hiroshi
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依托单位:
Empirical study on arithmetic department class that intends understanding and use of mathematical principle.
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批准号:19500713
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2007
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负责人:NAKANO Hiroshi
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依托单位:
Therapeutic approach against surgical injury of diseased liver : Proteomics approach
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批准号:18591528
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
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财政年份:2006
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负责人:NAKANO Hiroshi
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依托单位:
Modification of the Hepatic Mitochondrial Proteome in Response to Ischemic Preconditioning Following Ischemia-Reperfusion Injury of the Rat Steatotic Liver.
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批准号:16591367
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:NAKANO Hiroshi
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依托单位:
Practical Approach to Teaching Scientific Fundamentals from Computer Mechanisms using Multimedia
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批准号:15606012
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2003
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负责人:NAKANO Hiroshi
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依托单位:
EFFECT OF ACETOALDEHYDE ON THE GENE EXPRESSION OF TYPE IV COLLAGENASES AND THOSE INHIBITORS IN CULTURED HUMAN ITO-CELLS
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批准号:08670613
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:NAKANO Hiroshi
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依托单位:
Research for investigating treatment of fulnilnant hepatic failure : An experimental study of auxiliary temporal partial orthotopic liver transplantation using living-donor partial liver
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批准号:08557078
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$6.27万
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财政年份:1996
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负责人:NAKANO Hiroshi
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依托单位:
Research for pathophysiology and therapeutic means of hepatic oxidatiye stress in obstructive iaundice.
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批准号:07671424
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:NAKANO Hiroshi
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依托单位:
APPLICATION OF NEURAL NETWORK TO THE ASSESSMENT FOR THE DEGREE OF HEPATIC FIBROSIS
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批准号:06670577
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.32万
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财政年份:1994
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负责人:NAKANO Hiroshi
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依托单位:
Basic Study on the Description of Structure of Japanese Language for Analysis and Generation of Context
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批准号:06401011
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$5.7万
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财政年份:1994
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负责人:NAKANO Hiroshi
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依托单位:
STUDY OF CONSTRUCTION AND USE OF THESAURUS OF JAPANESE WORDS AS DATABASE
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批准号:04451082
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.18万
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财政年份:1992
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负责人:NAKANO Hiroshi
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依托单位:
海外基金