结直肠肝转移瘤接受奥沙利铂化疗后肝窦内皮细胞损伤机制的蛋白质组学分析。-猫眼课题宝

结直肠肝转移瘤接受奥沙利铂化疗后肝窦内皮细胞损伤机制的蛋白质组学分析。

批准号：

22591509

负责人：

NAKANO Hiroshi

金额：

$3.0万

依托单位：

St. Marianna University School of Medicine

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2010

资助国家：

日本

项目状态：

已结题

起止时间：

2010 至 2012

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591509/

关键词：

大腸癌肝転移術前化学療法 oxaliplatin-based chermotherapy sinusoidal obstruction syndrome プロテオミクス glutathione S-transferase M1 sphingosine 1 phosphate 大腸癌肝転移肝切除術前化学療法肝障害 Blue liver Peroxiredoxin 6 化学療法関連肝障害ジヌソイド閉塞症候群オキザリプラチン Aldehyde

中文摘要

翻译

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英文摘要

Oxaliplatin-based chemotherapy in patients with colorecatl liver metastases has been shown to be significantly associated with sinusoidal obstruction syndrome (SOS). In the present study, our proteomics study using 2-Dimensional electrophoresis and LC/MS/MS showed that Peroxiredoxin6、Aldehyde dehydrogenase 2、 α-methylacetyl-CoA racemase、Protein disulfide-isomerase A3、60-S-acid ribosomal protein P0、and Glutathione S-transferase M1 (GST-M1) significantly differed as compared with the control sinusoidal cells. Among them, GST-M1 significantly decreased in human sinusoidal endothelial cells after the administration of oxaliplatin. In addition, an administration of sphingosine 1 phosphate (S1P), which has a protective effect on sinusoidal endothelial injury, significantly attenuate the oxaliplatin-induced sinusoidal injury and showed the maintenance of GST-M1 concentration. These results suggests thatGST-M1 and S1P have a crucial role of oxaliplatin-induced sinusoidal endothelial inj.

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会议论文

Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes.

原代培养人肝细胞中维持 CYP3A4 和 ATP 结合盒转运蛋白活性的培养条件的比较研究。

DOI： --

发表时间： 2011

期刊：

Journal of Pharmacological Sciences. vol.115、No.4

影响因子： --

作者：

[Yuko Takeba, Naoki Matsumoto, Sachiko Takenoshita-Nakaya, Yoshie Harimoto, Toshio Kumai, Yuichi Kinoshita, Hiroshi Nakano, Takehito Ohtsubo, Shinichi Kobayashi]

通讯作者： Shinichi Kobayashi

晚期/复发性结直肠癌化疗相关的肝损伤：通过脾脏体积、AST/血小板比和蛋白质组学分析识别未接受化疗的患者

DOI： --

发表时间： 2012

期刊：

影响因子： --

作者：

[中野浩, 他, 中野浩]

通讯作者：中野浩

Splenomegaly in oxaliplatin-naive patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy in stage IV or recurrent colorectal cancer

IV 期或复发性结直肠癌化疗前天冬氨酸转氨酶与血小板的比率可以预测未接受奥沙利铂治疗的患者因化疗相关肝毒性而出现的脾肿大

DOI： --