Epidemiological study for association between Helicobacter infection and gastrointestinal diseases

螺杆菌感染与胃肠道疾病关联的流行病学研究

• 批准号: 22406026
• 负责人: AZUMA Takeshi
• 金额: $ 12.48万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22406026/
• 关键词: Helicobacter感染; 消化器疾患; 疫学調査; ピロリ菌; ハイルマニ菌; アジア; H.pylori; 感染症

In this study, we investigated the relationship between Helicobacterinfection (H. pylori and H. suis) and gastrointestinal diseases in Asian and African countries. H. pyloriis a group I carcinogen in human. CagA is a most important virulent factor of H. pyloriassociate with gastric cancer. The prevalence of East Asian CagA was significantly higher in patients with gastric cancer than in patients with chronic gastritis. The much greater magnitude of risk observed with East Asian CagA-positive H. pyloriinfection. Therefore, patients harboring East Asian CagA-positive H. pylori are at a higher risk for developing gastric cancer than those infected with Western CagA-positive strains. H. suis, which belongs to the Helicobacterfamily just like H. pylori, was found in the stomachs of various animals including cats, dogs and pigs, and furthermore humans. H. suis infection caused gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Th1 host response was predominant in H. pyloriinfection. In contrast, both Th1 and Th2 host response were up-regulated in H. suisinfection.

本研究探讨了幽门螺杆菌（H. pylori和H. suis）和胃肠道疾病。H.幽门螺杆菌是人类I类致癌物。CagA是H. pylori与胃癌相关。东亚CagA在胃癌患者中的患病率显著高于慢性胃炎患者。东亚CagA阳性H。幽门感染因此，携带东亚CagA阳性H.幽门螺杆菌感染者比感染西方CagA阳性菌株的人患胃癌的风险更高。H. suis与H.幽门螺杆菌，在各种动物的胃中发现，包括猫、狗和猪，以及人类。H.猪感染引起胃粘膜相关淋巴组织（MALT）淋巴瘤。H.幽门感染与此相反，在H.猪感染。

项目成果

Birth and death of genes linked to chromosomal inversion

• DOI: 10.1073/pnas.1012579108
• 发表时间: 2011-01-25
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Furuta, Yoshikazu;Kawai, Mikihiko;Kobayashi, Ichizo
• 通讯作者: Kobayashi, Ichizo

Helicobacter pylori strain diversities in Asia

亚洲幽门螺杆菌菌株多样性

• 作者: Jesmin S;et al.;Azuma T
• 通讯作者: Azuma T

IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection

• DOI: 10.1111/j.1574-695x.2011.00823.x
• 发表时间: 2011-10-01
• 期刊: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
• 作者: Mimura, Takuya;Yoshida, Masaru;Azuma, Takeshi
• 通讯作者: Azuma, Takeshi

Dual roles of CagA protein in Helicobacter pylori-induced chronic gastritis in mice

• DOI: 10.1016/j.bbrc.2011.07.081
• 发表时间: 2011-08-26
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kido, Masahiro;Watanabe, Norihiko;Chiba, Tsutomu
• 通讯作者: Chiba, Tsutomu

Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates the bacterial infection in mice.

胃上皮中表达的新生儿 IgG Fc 受体 (FcRn) 可调节小鼠的细菌感染。

• 发表时间: 2010
• 作者: Jesmin S;et al.;栗本将多;Takeshi Azuma;ヤハヤ ベンスレイマン
• 通讯作者: ヤハヤ ベンスレイマン