Epidemiological study for association between Helicobacter infection and gastrointestinal diseases

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In this study, we investigated the relationship between Helicobacterinfection (H. pylori and H. suis) and gastrointestinal diseases in Asian and African countries. H. pyloriis a group I carcinogen in human. CagA is a most important virulent factor of H. pyloriassociate with gastric cancer. The prevalence of East Asian CagA was significantly higher in patients with gastric cancer than in patients with chronic gastritis. The much greater magnitude of risk observed with East Asian CagA-positive H. pyloriinfection. Therefore, patients harboring East Asian CagA-positive H. pylori are at a higher risk for developing gastric cancer than those infected with Western CagA-positive strains. H. suis, which belongs to the Helicobacterfamily just like H. pylori, was found in the stomachs of various animals including cats, dogs and pigs, and furthermore humans. H. suis infection caused gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Th1 host response was predominant in H. pyloriinfection. In contrast, both Th1 and Th2 host response were up-regulated in H. suisinfection.