Metabolome analysis in the gastric carcinogenesis induced by the cross-talk between Helicobacter pylori and host.
Metabolome analysis in the gastric carcinogenesis induced by the cross-talk between Helicobacter pylori and host.
批准号:
21390228
负责人:
AZUMA Takeshi
金额:
$11.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
测定了日本分离的4株幽门螺杆菌的全基因组序列。一个系统发育树连接明确的核心基因支持东亚血统的分歧,从欧洲血统的祖先,然后从美洲血统的祖先。系统发育分析显示,在剧目的外膜蛋白的一个很大的差异。结果定义了H. pylori东亚谱系,并提供必要的信息,了解其发病机制。我们研究了代谢组学分析,液相色谱-质谱,气相色谱-质谱。乳酸在H. pylori感染的AGS(胃癌细胞系)细胞和胃癌患者血清。相比之下,苹果酸在H. pylori感染的AGS细胞和胃癌患者血清。
英文摘要
The complete genome sequences of four Helicobacter pylori strains isolated from Japan were determined. A phylogenetic tree of concatenated well-defined core genes supported divergence of the East Asian lineage from the European lineage ancestor, and then from the Amerind lineage ancestor. Phylogenetic profiling revealed a large difference in the repertoire of outer membrane proteins. The results define H. pylori East Asian lineages and provide essential information for understanding their pathogenesis.We investigated metabolome analysis using liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry. Lactic acid was upregulated in H. pylori infected AGS(gastric cancer cell line) cells and serum of gastric cancer patients. In contrast, malic acid was downregulated in H. pylori infected AGS cells and serum of gastric cancer patients.
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DOI:
10.1111/j.1574-695x.2011.00823.x
发表时间:
2011-10-01
期刊:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
影响因子:
--
作者:
[Mimura, Takuya, Yoshida, Masaru, Azuma, Takeshi]
通讯作者:
Azuma, Takeshi
DOI:
10.1073/pnas.1012579108
发表时间:
2011-01-25
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Furuta, Yoshikazu, Kawai, Mikihiko, Kobayashi, Ichizo]
通讯作者:
Kobayashi, Ichizo
DOI:
10.1016/j.micinf.2009.12.007
发表时间:
2010-03-01
期刊:
MICROBES AND INFECTION
影响因子:
5.8
作者:
[Hirai, Itaru, Sasaki, Tadahiro, Wangroongsarb, Piyada]
通讯作者:
Wangroongsarb, Piyada
DOI:
10.1016/j.clim.2008.09.016
发表时间:
2009-03
期刊:
Clinical immunology (Orlando, Fla.)
影响因子:
--
作者:
[Yoshida A, Isomoto H, Hisatsune J, Nakayama M, Nakashima Y, Matsushima K, Mizuta Y, Hayashi T, Yamaoka Y, Azuma T, Moss J, Hirayama T, Kohno S]
通讯作者:
Kohno S
DOI:
10.1016/j.micinf.2011.02.007
发表时间:
2011-07-01
期刊:
MICROBES AND INFECTION
影响因子:
5.8
作者:
[Yamamoto, Koji, Tanaka, Hiroshi, Azuma, Takeshi]
通讯作者:
Azuma, Takeshi
共 14 条
Medical application of atmospheric nonthermal plasmas.
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批准号:26670382
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2014
-
负责人:AZUMA Takeshi
-
依托单位:
Management of Helicobacter infection and its related gastrointestinal diseases in Asia
-
批准号:25305027
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.23万
-
财政年份:2013
-
负责人:AZUMA Takeshi
-
依托单位:
Development of endoscopic treatment system using laser
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批准号:24659366
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
-
负责人:AZUMA Takeshi
-
依托单位:
Development of MR endoscopy
-
批准号:22659146
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.07万
-
财政年份:2010
-
负责人:AZUMA Takeshi
-
依托单位:
Epidemiological study for association between Helicobacter infection and gastrointestinal diseases
-
批准号:22406026
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.48万
-
财政年份:2010
-
负责人:AZUMA Takeshi
-
依托单位:
Epidemiological research for the relationship between Helicobacter pylori infection and gastrointestinal diseases in Asia
-
批准号:19406025
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.82万
-
财政年份:2007
-
负责人:AZUMA Takeshi
-
依托单位:
Development of order-made medicine for gastric cancer prevention
-
批准号:18390217
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.89万
-
财政年份:2006
-
负责人:AZUMA Takeshi
-
依托单位:
Analysis of risk factors for gastric cancer in order to construct tailor-made medicine for gastric cancer
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批准号:15390231
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.94万
-
财政年份:2003
-
负责人:AZUMA Takeshi
-
依托单位:
Function analysis of Helicobacter pylori cag pathogenicity island
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批准号:13670502
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.56万
-
财政年份:2001
-
负责人:AZUMA Takeshi
-
依托单位:
Analysis of gastric epithelial lineage
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批准号:11670488
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
-
财政年份:1999
-
负责人:AZUMA Takeshi
-
依托单位:
Cathepsin E expression in pancreatic cancer
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批准号:09670525
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:AZUMA Takeshi
-
依托单位:
Cancer specific expression of Cathepsin E in pancreas
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批准号:06670531
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.54万
-
财政年份:1994
-
负责人:AZUMA Takeshi
-
依托单位:
Rapid diagnostic test for Helicobacter pylori using endoscopic urease probe
-
批准号:06557039
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$5.63万
-
财政年份:1994
-
负责人:AZUMA Takeshi
-
依托单位:
海外基金