Studies on motor axon guidance in a spontaneous mutant mouse

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The molecular mechanisms that regulate guidance of spinal motor axons to their target muscles are not known. In this study, we tried to elucidate it using a spontaneous mutant mouse that shows abnormalities in a particular motor trajectory. We examined the sequences of the genes in the critical region but failed to find any mutation responsible for the mutant phenotype. However, we found that the expression levels of several genes present in the critical region are changed in the mutant mice, suggesting the abnormalities in gene regulation.