α-synuclein-positive neurites as an early diagnostic indicator

我们追踪了人类大脑中的Lewy病理学，并证明了其起始于远端轴突和随后的向心延伸。远端轴突的预期功能障碍，可检测为心肌对MIBG的摄取减少，是早期和特异性诊断路易体病的合理候选者。相比之下，tau蛋白沉积开始于树突中的4 R沉积物，其可以进行向3R tau蛋白的向心进展过渡，如我们用3R/4 R tau蛋白的双标记所证明的。我们还建立了一种新的方法来比较光镜和免疫电镜检查结果相同的病变，这是潜在的有用的桥梁分子变化病变的形成。

We traced the Lewy pathology in human brain and demonstrated its initiation at distal axon and subsequent centripetal extension. Expected dysfunction at distal axons, detectable as a decreased myocardial uptake of MIBG, is a reasonable candidate for early and specific diagnosis of Lewy body disease. In contrast, tau deposition start as 4R deposits in dendrites, which may undertake transition to 3R tau with centripetal progression, as we demonstrated with double labeling for 3R/4R tau. We also established a new method to compare light and immunoelectron microscopic findings of the same lesion, which is potentially useful to bridge molecular changes to lesion formation.