Analysis of Protein adducts derived from environmental carcinogensand their biological activities

3-硝基苯甲酮是一种新发现的环境致癌物质。在这项研究中，为了了解NBA对蛋白质的修饰，进行了几个实验。NBA被发现以适中的产率修饰赖氨酸、半胱氨酸和色氨酸。通过独立的化学合成揭示了经NBA修饰的赖氨酸的化学结构。这种物质是在NBA恳求的蛋白质水解物中发现的。然而，该化合物的体内形成在本研究中并未被指定。

3-nitrobenzanthrone is a newly discovered environmental carcinogen. In this study,in order to know protein modification with NBA, several experiments were performed. NBA was found to modify lysine, cysteine and tryptophan in moderate yields. Chemical structure of lysine modified with NBA was also revealed by the independentchemical synthesis. This material was found in protein hydrolysates that has beentreated with NBA. Howeveri, in vivo formation of this compound was not assigned inthis study.