Role of stress response signal transduction pathway in trichothecene production in Fusarium graminearum

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The deletion mutants of FgATF1 gene which encodes a putative transcription factor regulated by stress response MAP kinase FgOS2 were isolated and characterized in Fusarium graminearum. Δ FgATF1 strain lack the ability to produce trichothecenes, whereas FgATF1 deletion in an aconidial strain did not affect trichothecene production. These results suggest that FgATF1 indirectly regulates the trichothecene synthesis probably through asexual differentiation. Furthermore we identified 11 genes which are regulated under the stress response MAP kinase pathway, they included various genes such as glycerol dehydrogenase, conidial catalase, clock-controlled genes, gluconeogenesis key enzymes, and cell wall enzymes.