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Analysis of sex hormone actions in noninvasive breast carcinoma

Analysis of sex hormone actions in noninvasive breast carcinoma
性激素在非浸润性乳腺癌中的作用分析
批准号:
22590305
负责人:
SUZUKI Takashi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We aimed to characterize the estrogen functions in noninvasive breast carcinomas (DCIS), precursor lesion of the invasive carcinomas (IDC).Results of our present study have demonstrated that (1) estrogen functions in DCIS were different from those in IDC, andC-MYB, RbAp46 and survivin played important roles in DCIS, and (2) intratumoral estrogen concentration in DCIS was markedly decreased following aromatase inhibitor letrozole treatment, and the expression of a great majority of estrogen-induced genes andproliferative activity were markedly decreased following the treatment.These results suggest that estrogen is mainly produced by aromatase in DCIS, and aromatase inhibitors may potently inhibit estrogen actions in these patients.
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KLF5 in human breastcancer
KLF5 在人类乳腺癌中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Takagi K, Miki Y, Onodera Y, 以下4名略, Suzuki T]
通讯作者: Suzuki T
KLF5 in human breast cancer
KLF5 在人类乳腺癌中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Takagi K, Miki Y, Onodera Y, 以下4名略, Suzuki T]
通讯作者: Suzuki T
DOI: 10.1074/jbc.m110.156877
发表时间: 2011-01-07
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Oyama, Masaaki, Nagashima, Takeshi, Okada-Hatakeyama, Mariko]
通讯作者: Okada-Hatakeyama, Mariko
Expression of the zinc finger protein (PLZF) in human breast carcinoma
锌指蛋白(PLZF)在人乳腺癌中的表达
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Takagi K, Miki Y, Onodera Y, 以下3名略, Suzuki T.]
通讯作者: Suzuki T.
11
    Possible growth signal transduction between Th17 cells and breast cancer cells
    • 批准号:
      19K09065
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2019
    • 负责人:
      SUZUKI Takashi
    • 依托单位:
    Analyses on multiple factors related to evaluation of antioxidant function of northern berries
    • 批准号:
      25292017
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.65万
    • 财政年份:
      2013
    • 负责人:
      SUZUKI Takashi
    • 依托单位:
    Development and publicizing of the simple and low-priced drop-sizing system for dispersive two-phase flows utilizing an image sensor
    • 批准号:
      25420116
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      SUZUKI Takashi
    • 依托单位:
    Non-invasive quantitative in vivo optical imaging of cerebral blood flow and metabolism
    • 批准号:
      25870370
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2013
    • 负责人:
      SUZUKI Takashi
    • 依托单位:
    海外基金