Analysis of androgen actions in human breast carcinoma
Analysis of androgen actions in human breast carcinoma
批准号:
19590339
负责人:
SUZUKI Takashi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
Previous studies have demonstrated that androgens exert anti-proliferative effects in the breast carcinoma, but the detailed mechanisms remain unclear. Results of our present study demonstrated that (1) androgen actions were markedly suppressed by estrogens in the breast carcinoma, (2) an estrogen-producing enzyme, aromatase, also plays as a negative regulator of intratumoral androgen production, (3) androgen actions were increased in the breast carcinoma treated with an aromatase inhibitor, and (4) 17βHSD2 was identified as an androgen-induced gene in the breast carcinoma, which was involved in the anti-proliferative effects of androgens on the breast carcinoma.
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DOI:
10.1677/erc-06-0005
发表时间:
2007-06-01
期刊:
ENDOCRINE-RELATED CANCER
影响因子:
3.9
作者:
[Suzuki, Takashi, Inoue, Akio, Sasano, Hironobu]
通讯作者:
Sasano, Hironobu
Aromatase in human breast carcinoma as a key regulator of intratumoral sex steroid concentrations
人类乳腺癌中的芳香酶作为肿瘤内性类固醇浓度的关键调节剂
DOI:
--
发表时间:
2008
期刊:
Endocr J. 55(3)
影响因子:
--
作者:
[Suzuki T, Miki Y, Akahira J, Moriya T, Ohuchi N, Sasano H.]
通讯作者:
Sasano H.
17β-hydroxysteroid dehydrogenase type 12 in human breast carcinoma : a prognostic factor via potential regulation of fatty acids synthesis
人乳腺癌中的 17β-羟基类固醇脱氢酶 12 型:通过潜在调节脂肪酸合成的预后因素
DOI:
--
发表时间:
2009
期刊:
Cancer Res. 69
影响因子:
--
作者:
[Nagasaki S, Suzuki T, Miki Y, Akahira J, Kitada K, Ishida T, Handa H, Ohuchi N, Sasano H.]
通讯作者:
Sasano H.
乳癌 (分担章:乳癌におけるアロマターゼ研究)
乳腺癌(章节:乳腺癌中的芳香酶研究)
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[鈴木 貴, 森谷卓也, 笹野公伸]
通讯作者:
笹野公伸
DOI:
10.1158/0008-5472.can-06-3105
发表时间:
2007-04-15
期刊:
CANCER RESEARCH
影响因子:
11.2
作者:
[Miki, Yasuhiro, Suzuki, Takashi, Sasano, Hironobu]
通讯作者:
Sasano, Hironobu
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