Molecular characterization of a novel cyanide-sensitive quinol oxidase of Trypanosoma cruzi
Molecular characterization of a novel cyanide-sensitive quinol oxidase of Trypanosoma cruzi
批准号:
19590434
负责人:
SUZUKI Takashi
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In this analysis, properties of Trypanosoma cruzi alterative oxidase (TcrAOX) were analyzed. Phylogenetic analysis demonstrated that TcrAOX molecule was placed distantly from other AOX molecules. When TcrAOX was expressed in Escherichia coli cells, the E.coli cells showed increased growth, suggesting an oxidase activity of TcrAOX. In T.cruzi cells, TcrAOX was localized in mitochondria. Over-expression of TcrAOX in T.cruzi cells caused increased growth. Depletion trials of both alleles of TcrAOX failed. Thus TcrAOX was considered to possess an important role for T.cruzi-growth, possibly oxidase activity, while its substrate did not seem to be quinol.
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Establishment of a Polymerase Chain Reaction Method for Detection of Escherichia coli in Amniotic Fluid in Patients with Chorioamnionitis
绒毛膜羊膜炎患者羊水中大肠杆菌聚合酶链反应检测方法的建立
DOI:
10.1159/000142143
发表时间:
2008
期刊:
Fetal Diagnosis and Therapy
影响因子:
2.2
作者:
[G. A. Daoud, Yoshikatsu Suzuki, Tamao Yamamoto, Takashi Suzuki, N. Suzumori, M. Tanemura]
通讯作者:
M. Tanemura
Genome-scale Prioritization of Drug Targets : TDRtargets. org.
药物靶点的基因组规模优先排序:TDRtargets。
DOI:
--
发表时间:
2008
期刊:
Nature Reviews Drug Discovery 7
影响因子:
--
作者:
[Aguero F, Berriman M, Buckner F, Campbell B, Carmona S, Crowther G, Hertz-Fowler C, Hopkins A, Al-Lazikani B, McAllister G, Nwaka S, Overington J, Pain A, Paolini G, Ralph S, Riechers A, Roos S D, Sali A, Shanmugam D, Suzuki T, Verlinde L C, Van Voorhis C]
通讯作者:
Van Voorhis C
アフリカトリパノソーマ原虫の「動き」関連遺伝子の解析
非洲锥虫原生动物“运动”相关基因分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[鈴木高史, 大島茂, 大橋光子, 籔義貞, 三浦裕]
通讯作者:
三浦裕
Trypanosoma brucei vacuolar protein sorting 41(VPS41)is required for intracellular iron utilization and maintenance of normal cellular morphology.
布氏锥虫液泡蛋白分选 41 (VPS41) 是细胞内铁利用和维持正常细胞形态所必需的。
DOI:
--
发表时间:
2007
期刊:
Parasitology 134
影响因子:
--
作者:
[Lu Shaohong, et. al.]
通讯作者:
et. al.
Molecular analysis of "movement"-related genes of African trypanosome species.
非洲锥虫物种“运动”相关基因的分子分析。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Suzuki T, Ohshima S, Ohashi M, Yabu Y, Miura Y.]
通讯作者:
Miura Y.
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