Analysis of the histogenesis of thymoma

胸腺瘤的组织发生分析

• 批准号: 22590313
• 负责人: TAKAHASHI Kiyoshi
• 金额: $ 2.66万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590313/
• 关键词: 胸腺腫; 免疫組織化学; 組織発生; 胸腺癌; 呼吸器; 縦隔

We examined thymomas immunohitochemically. Type A thymoma (14 cases) were composed solely of pCK+/EMA-/VM)-/CDN-1+ shout spindle epithelial cells. Thy nor TCDM were not found at all. Metaplastic thymoma (1 case) was found to be mosaic of two different components, pCK+/VM-/EMA-/CDN-1+ tumor cells of type A thymoma and pCK-/VM+/EMA+/CDN-1- fibroblastoid metaplastic epithelial cells (FMECs). In the majority of type AB thymoma (14 of 19 cases), type A-like areas were composed of FMECs. In contrast, type A-like areas of remaining 5 cases were composed of type A thymoma cells. These findings indicate that there are two different subtypes in type AB thymoma, metaplastic type AB thymoma and conventional type AB thymoma. The presence of a considerable numbers of TCDM in types B thymomas and β5t-immunoreactivity of tumor cells indicates that type B thymomas are basically tumor of c-TECs. We also found that there are two subtypes of type B3 thymoma, the differentiated subtype containing TCDM and the anaplastic subutype lucking TCDM, although clinical between them remains unclear. We also found that type B3 thymoma are able to be distinguished from thymic carcinoma by proper use of markers such as thy/TCDM, β5t, c-Kit and/or CD5

我们对胸腺瘤进行了免疫组化检查。A型胸腺瘤（14例）仅由pCK+/EMA-/VM）-/CDN-1+梭形上皮细胞组成。根本没有找到您的TCDM。化生性胸腺瘤（1例）由A型胸腺瘤的pCK+/VM-/EMA-/CDN-1+肿瘤细胞和pCK-/VM+/EMA+/CDN-1-成纤维细胞样化生上皮细胞（FMECs）两种不同成分镶嵌而成。在大多数AB型胸腺瘤（19例中的14例）中，A型样区由FMEC组成。5例胸腺瘤样区由A型胸腺瘤细胞组成。提示AB型胸腺瘤可分为化生型和常规型两种亚型。B型胸腺瘤中存在大量的TCDM和肿瘤细胞的β 5 t免疫反应性表明B型胸腺瘤基本上是c-TEC的肿瘤。我们还发现B3型胸腺瘤有两种亚型，即含有TCDM的分化亚型和不含TCDM的间变性亚型，尽管它们之间的临床关系尚不清楚。我们还发现，适当使用thy/TCDM、β 5 t、c-Kit和/或CD 5等标志物，可以区分B3型胸腺瘤和胸腺癌

项目成果

AB型胸腺腫の免疫組織化学的検討

AB型胸腺瘤的免疫组织化学研究

• 发表时间: 2012
• 作者: 三木友香理;普門拓己;林 敦志;高橋聖之
• 通讯作者: 高橋聖之

B3型胸腺腫のsubtype分類の試みとその意義についての検討:第二報

B3胸腺瘤亚型分类的尝试及其意义研究：第二份报告

• 发表时间: 2012
• 作者: 普門拓己;林 敦志;三木友香理;高橋聖之
• 通讯作者: 高橋聖之

The Immunohistochemical distinction of thymic carcinoma from lung squamous cell carcinoma and type B3 thymoma.

胸腺癌与肺鳞状细胞癌和B3型胸腺瘤的免疫组织化学区别。

• 发表时间: 2012
• 作者: Atsushi Hayashi;Yukari Miki;Kiyoshi Takahashi
• 通讯作者: Kiyoshi Takahashi

胸腺癌および肺扁平上皮癌における免疫組織学的検討

胸腺癌和肺鳞癌的免疫组织学检查

• 发表时间: 2012
• 作者: 林 敦志;高橋聖之;三木友香理;普門拓己
• 通讯作者: 普門拓己

The Evaluation of Immunohistochemical Markers and Thymic Cortical Microenvironmental Cells in Distinguishing Thymic Carcinoma from Type B3 Thymoma or Lung Squamous Cell Carcinoma

• DOI: 10.3960/jslrt.53.9
• 发表时间: 2013-06-01
• 期刊: JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY
• 影响因子: 1.5
• 作者: Hayashi, Atsushi;Fumon, Takumi;Takahashi, Kiyoshi
• 通讯作者: Takahashi, Kiyoshi