Evaluation of functional roles of estrogen related receptors(ERRs) on differentiation of mesenchymal-derived cells using induced pluripotent stem cells.

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To elucidate the functional roles of estrogen related receptors(ERRs) on the reprogramming and differentiation of mesenchymal-derived cells, we examined combined methods achieving efficient reprogramming and mesenchymal-derived cell differentiation using viral vector systems. This made a partly improved efficiency of differentiation, while it was demonstrated that differentiation potential of iPS cells varied widely between clones. In this study, we established the basis for evaluation of ERR functions in reprogramming and differentiation, while these results suggest that generation of genetically and functionally homogenous iPS cells is necessary for in vivo evaluation of gene function as well as clinical application of iPS cells.