Investigation to determine a mechanism for T cell regulatory effects induced by treatment with high-dose immunoglobulin injection after organ transplantation.

在本研究中，我们的目的是确定器官移植后大剂量免疫球蛋白注射治疗诱导T细胞调节作用的机制。通过人淋巴细胞反应实验，我们证实了Ig G中的Fc部分对同种异体反应性T细胞的抑制作用。我们发现，肽289对同种异体反应性T细胞的增殖有抑制作用。然而，其抑制程度无法与常规免疫抑制剂相提并论。此外，我们开发了一种新的方法来分析体外同种异体反应性T细胞中的STAT信号。

In the present study, we aimed to determine a mechanism of T cell regulatory effects induced by treatment with high-dose immunoglobulin injection after organ transplantation. By use of human lymphocyte reaction assay, we have proven that the Fc-part in IgG is responsible for the inhibiting effects on alloreactive T cells. We found that Peptide 289 inhibited proliferation of alloreactive T cells. However, its inhibitory extent was not comparable to conventional immunosuppressants. In addition, we developed a novel method to analyze STAT-signaling in alloreactive T cells in vitro.