The effect of Del-1 by in vivo gene therapy

在裸鼠背部皮下注射口腔鳞状细胞癌细胞系：SCCKN，制成移植瘤。采用pFasL或pFasL/E3 D1基因治疗移植瘤。每周注射pFasL或pFasL/E3 D1基因。对照组和/或pFasL基因治疗组小鼠在49天内全部死亡<th>。而pFasL/E3 D1组小鼠49天存活率为87%<th>。证实pFasL/E3 D1的剂量控制肿瘤的增加，并且在移植肿瘤中存在存活益处。

A nude mouse was injected an oral squamous cell carcinoma cell line : SCCKN at the subcutaneously back and made a transplant tumor. The transplant tumor was treated by the gene therapy of pFasL or pFasL/E3D1 gene. The pFasL or pFasL/E3D1 gene was injected every week. The all mice of control group and/or treated of pFasL gene group were dead of 49^<th> days. But, the survival rate of mice with treated by pFasL/E3D1 was 87% at 49^<th> days. It was confirmed that the dosage of pFasL/E3D1 controls the increase of tumor, and there is a survival benefit in a transplant tumor.