The effected of cancer gene therapy for Del 1 and Fas L
The effected of cancer gene therapy for Del 1 and Fas L
批准号:
20791551
负责人:
KITANO Hisataka
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
制备FasL和FasL/E3 D1并转染癌细胞。在该检查中,通过Del 1将转染的细胞浓缩成用于ECM的FasL蛋白。该蛋白对细胞凋亡和二次基因转移有一定的影响.结果表明,该组织可以将其浓缩,而不会使Del 1的组成结构域失去与各种生物活性物质的功能。
英文摘要
FasL and FasL/E3D1 was made and transfected for a cancer cell. In this examination, the transfected cells were concentrated to FasL protein for ECM by Del1. Andmore, the protein was effected to apoptosis and, second gene transfer. It was shown that the organization could concentrate it without a composed domain of Del1 losing the function with various kinds of bioactive substances.
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DOI:
10.1016/j.bbrc.2010.02.076
发表时间:
2010-03-19
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Kitano, Hisataka, Kokubun, Shinichiro, Hidai, Chiaki]
通讯作者:
Hidai, Chiaki
The Extracellular Matrix Protein Dell Induces Apoptosis viaits Epidermal Growth Factor Motif.
细胞外基质蛋白 Dell 通过其表皮生长因子基序诱导细胞凋亡。
DOI:
--
发表时间:
2010
期刊:
Biochemical and Biophysical Research Communications 393(4)
影响因子:
--
作者:
[Hisataka Kitano, Shinichiro Kokubun, Chiaki Hidai.]
通讯作者:
Chiaki Hidai.
The Del1 deposition domain can immobilize 3α-hydroxysteroid dehydrogenase in the extracellular matrix without interfering with enzymatic activity
Del1沉积结构域可以将3α-羟基类固醇脱氢酶固定在细胞外基质中而不干扰酶活性
DOI:
--
发表时间:
2009
期刊:
Bioprocess Biosyst Eng. 32(5)
影响因子:
--
作者:
[Chiaki Hidai, Hisataka Kitano, Shinichiro Kokubun]
通讯作者:
Shinichiro Kokubun
The Dell deposition domain can immobilize 3 a -hydroxysteroi d dehydrogenase in the extracellular matrix without interferi ng with enzymatic activity
Dell沉积结构域可以将3α-羟基类固醇脱氢酶固定在细胞外基质中而不干扰酶活性
DOI:
--
发表时间:
2008
期刊:
Bioprocess Biosyst Eng (in press)
影响因子:
--
作者:
[Chiaki Hidai, Hisataka Kitano, Shinichiro Kokubun]
通讯作者:
Shinichiro Kokubun
Effect of combination therapy of gene therapy with a Del1 and antibody-drug
-
批准号:18K09800
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2018
-
负责人:KITANO Hisataka
-
依托单位:
Clarification of mechanism of gene therapy with a Del1
-
批准号:15K11273
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2015
-
负责人:KITANO Hisataka
-
依托单位:
The completion of protocol for gene therapy by Del1
-
批准号:24593012
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2012
-
负责人:KITANO Hisataka
-
依托单位:
The effect of Del-1 by in vivo gene therapy
-
批准号:22792019
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2010
-
负责人:KITANO Hisataka
-
依托单位:
海外基金