Role of receptor glycosylation on the effects of narcotic analgesics

我们从野生来源的HMI近交系小鼠中建立了一个基因小鼠品系（Oprm1^<HMI/HMI>）。甩尾和热板实验显示，Oprm1^<HMI/HMI>基因小鼠吗啡诱导的抗伤感觉增强。这些数据表明，μ阿片受体的n -链糖基化会影响阿片镇痛药的效果。同源小鼠是分析体内μ阿片受体n -链糖基化效应的有用菌株。对n -连接μ阿片受体糖基化突变体的进一步研究将有助于开发有效的镇痛药。

We established a congenic mouse strain(Oprm1^<HMI/HMI>) from wild-derived HMI inbred mice. The Oprm1^<HMI/HMI> congenic mice exhibited increased antinociception induced by morphine in the tail-flick and hot-plate tests. These data indicated that N-linked glycosylation of theμopioid receptor would influence the effects of opioid analgesics. The congenic mouse is useful strain for analyzing the effects of N-linked glycosylation of theμopioid receptor in vivo. The further studies with mutants of the N-linkedμopioid receptor glycosylation would absolutely contribute to the development of effective analgesics.