The Impact of Intensive Glycemic Control on Stablization of Coronary Vulnerable Plaque in Patients with Diabetes Mellitus

对70例急性心肌梗死患者的3条主要冠状动脉行OCT检查，评价糖尿病对冠状动脉易损斑块发生率的影响。罪魁祸首病变的TCFA发生率相似。然而，非罪魁祸首病变TCFAs在糖尿病患者中比在非糖尿病患者中更常见。然后，将糖尿病患者随机分配到强化血糖控制组，目标是糖化血红蛋白（HbA1c）水平<6.5%，或标准血糖控制组，目标是HbA1c水平< 7.0%。然而，在强化血糖控制患者和标准治疗患者之间，纤维帽厚度、脂质弧度和脂质成分体积的百分比变化没有显著差异。

OCT was performed in all 3 major coronary arteries of 70 patients with acute myocardial infarction to evaluate the impact of diabetes mellitus on the incidence of coronary vulnerable plaque. The incidences of TCFA at culprit lesions were similar. However, non-culprit-lesion TCFAs were observed more frequently in diabetic patients than in non-diabetic patients.Then, diabetic patients were randomly allocated to intensive glycemic control, targeting a glycosylated hemoglobin(HbA1c) level<6.5%, or standard glycemic control, targeting an HbA1c level of> 7.0%. However, there were no significant differences observed in percent changes in the fibrous cap thickness, lipid arc, and volume of lipidic component between patients with intensive glycemic control and patients with standard treatment.