A new strategy of the regulation of metabolic syndrome and cardiovascular diseases by the pharmacological targeting of cellular mechanical stress reactions.

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The effects of abdominal vibration were examined using obese mice with high-fat diet. Daily exposure of the 30-minutes-vibration induced downregulation of adipogenic factors and upregulation of anti-adipogenic factor, which consisted with decreasing adipose tissue triglyceride, some adipokines, and plasma free fatty acids. Furthermore, augmented expressions of several genes characteristic of anti-inflammatory M2 macrophages (Mφ) were detected. The effects of selective sPLA2 inhibitor (indoxam) on the pathogenicity of MCT-induced fatal pulmonary hypertensive rats (MCT-PHR) were also examined. Indoxam abolished the enhanced contractilities of the pulmonary arteries of MCT-PHR, which arteries show augmented expression of sPLA2-X isoform. In addition, administration of indoxam attenuated some inflammatory signs such as expression of proinflammatory cytokines and apoptosis in the lung, leading to a significant improvement of survival ratio in MCT-PHR.