The role of epithelial-mesenchymal transition in metastasis and progression of pediatric solid tumors.

上皮间质转化在儿科实体瘤转移和进展中的作用。

• 批准号: 22659317
• 负责人: KOMURO Hiroaki
• 金额: $ 2.14万
• 依托单位: The University of Tokyo (2011-2012)University of Tsukuba (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659317/
• 关键词: 上皮間葉移行; 小児固形腫瘍; 神経芽腫; 遺伝子発現; 浸潤転移; 予後; MYCN; Stage; 浸潤・転移; RT-PCR

The epithelial to mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. We investigated the role of EMT in the progression of Neuroblastoma (NB). Downregulation of KRT19 was highly associated with tumor progression in NB as well as metastasis in localized primary NB. Low expression of ERBB3 was also associated with progression of NB. Expression levels of EMT-related genes might become new promising prognostic markers for neuroblastoma.

上皮间质转化（EMT）是肿瘤侵袭和转移的重要机制。我们研究了EMT在神经母细胞瘤（NB）进展中的作用。KRT19的下调与NB中的肿瘤进展以及局部原发性NB中的转移高度相关。ERBB3的低表达也与NB的进展有关。EMT相关基因的表达水平可能成为神经母细胞瘤新的预后指标。

项目成果

Management of Cervicomediastinal Neuroblastoma Presenting With Life-threatening Tracheal Obstruction in Infancy

婴儿期出现危及生命的气管阻塞的颈纵隔神经母细胞瘤的治疗

• DOI: 10.1097/mph.0b013e31827b4747
• 发表时间: 2013
• 期刊: Journal of Pediatric Hematology/Oncology
• 作者: H. Komuro;Noriko Hoshino
• 通讯作者: Noriko Hoshino

Slow release of basic fibroblast growth factor (b-FGF) promotes growth of tracheal cartilage

碱性成纤维细胞生长因子（b-FGF）缓慢释放促进气管软骨生长

• 发表时间: 2013
• 期刊: J Pediatr Surg
• 影响因子: 2.4
• 作者: Ishimaru T;Komura M;Komura H;Otani Y;Komuro H;Sugiyma M;Terawaki K;Suzuki K;Tabata Y;Iwanaka T
• 通讯作者: Iwanaka T

Bile duct duplication as a cause of distal bowel gas in neonatal duodenal obstruction.

胆管重复是新生儿十二指肠梗阻远端肠积气的原因。

• DOI: 10.1016/j.jpedsurg.2011.09.018
• 发表时间: 2011
• 期刊: Journal of Pediatric Surgery
• 影响因子: 2.4
• 作者: Komuro H;Ono K;Hoshino N;Urita Y;Gotoh C;Fujishiro J;Shinkai T3Ikebukuro K
• 通讯作者: Shinkai T3Ikebukuro K

A case ofintrauterine gastric perforation in congenital diaphragmatic hernia.

先天性膈疝并发宫内胃穿孔1例。

• DOI: 10.1007/s00247-012-2435-x
• 发表时间: 2012
• 期刊: Pediatric Radiology
• 影响因子: 2.3
• 作者: Komuro H;Gotoh C
• 通讯作者: Gotoh C

A pediatric case of an unusual type of annular pancreas presenting with duodeno-pancreatic reflux.

一例罕见的环状胰腺儿科病例，表现为十二指肠胰腺反流。

• DOI: 10.1007/s00383-012-3065-y
• 发表时间: 2012
• 期刊: Pediatric Surgery International
• 影响因子: 1.8
• 作者: Komuro H;Gotoh C;Urita Y;Fujishiro J;Shinkai T
• 通讯作者: Shinkai T