The transgenerational effects in descendant mice after the every generational low dose-rate internal 137Cs radiation exposure as a Chernobyl simulation

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To investigate the transgenerational effects of chronic low dose-rate internal radiation exposure after the Chernobyl nuclear power plant accident, every generations of mice were maintained in the radioisotope facility with free access to drinking water containing 137CsCl (0 and 100 Bq/ml). Mice of the tenth generation (F10) were assessed gamma-H2AX foci in hepatic cell, micro nuclei test, chromosome aberration analysis, gene mutation in noncoding region (total 6000bps in 8 introns) and tumorigenicity of lung.Suppression of the tumor growth and increasing of the gamma-H2AX focus number were observed in 137Cs drinking mice, however, no significant difference was observed in the analyses of micro nuclei test, chromosome aberration, tumor incidence and gene mutation.