Dental pulp regeneration by stem cell transplantation: development of scaffolds and establishment of an animal experimental model
Dental pulp regeneration by stem cell transplantation: development of scaffolds and establishment of an animal experimental model
批准号:
23390433
负责人:
OKIJI Takashi
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This study was designed with the ultimate purpose of establishing a tooth pulp tissue engineering using transplantation of dental pulp stem cells, and conducted to select appropriate scaffolds and develop an experimental engineering system using rat molars. It was demonstrated that rat dental pulp is equipped with stem-like cells that coexpress CD146 and MAP1B and are distributed predominantly in theperivascular area. rat dental pulp by means of immunohistochemistry. Moreover, transplantation of rat mesenchymal stem cells into pulpotomized rat molars with a PLLA/Puramatrix scaffold resulted in the formation of new mineralized tissues at 4 weeks. These results suggest that the experimental model used in this study is useful for investigating the pulp tissue regeneratiopn using stem cell transplantation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Lipopolysaccharide-induced upregulation of antigen-presenting cell-related genes in macrophages in engineered-pulp
脂多糖诱导工程纸浆巨噬细胞中抗原呈递细胞相关基因的上调
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kaneko T]
通讯作者:
Kaneko T
Odontoblast response to cavitypreparation with Er:YAG laser in ratmolars: an immunohistochemicalstudy
成牙本质细胞对大鼠磨牙中 Er:YAG 激光制备腔体的反应:一项免疫组织化学研究
DOI:
10.1007/s10266-012-0078-x
发表时间:
2012
期刊:
Odontology Epub 2012 Jun 27
影响因子:
--
作者:
[Shigetani Y, Suzuki H, Ohshima H,Yoshiba K, Yoshiba N, Okiji T]
通讯作者:
Okiji T
ラット実験的歯髄炎における幹細胞関連マーカー発現の経時的検索
大鼠实验性牙髓炎中干细胞相关标记表达的时程搜索
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Suzuki H, Mochizuki A, Yoshimura K, Miyamoto Y, Kaneko K, Inoue T, Chikazu D, Takami M, Kamijo R, 齋藤正寛, 伊藤崇史]
通讯作者:
伊藤崇史
Handbook of Macrophages : Life Cycle, Functions and Diseases(分担執筆)
巨噬细胞手册:生命周期、功能和疾病(合著者)
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[吉岡俊彦, 白金由紀子, 石村瞳, 海老原新, 須田英明, 新垣理恵子 他, Kaneko T]
通讯作者:
Kaneko T
Immune-LCM of resident macrophages in cultured dental pulp tissues
培养牙髓组织中常驻巨噬细胞的免疫 LCM
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Uraiwan Chokechanachaisakul, Tomoatsu Kaneko, Yusuke Yamanaka, Reika Kaneko, Mitsuhiro Sunakawa, Takashi Okiji, and Hideaki Suda]
通讯作者:
and Hideaki Suda
共 27 条
An investigation of factors that promote dental pulp regeneration and stem cell differentiation in a rat model of coronal pulp regeneration
-
批准号:17H04380
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.98万
-
财政年份:2017
-
负责人:OKIJI Takashi
-
依托单位:
Investigation of determining factors for the reparative process of the dentin/pulp complex using a new experimental model
-
批准号:15K15699
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
-
财政年份:2015
-
负责人:OKIJI Takashi
-
依托单位:
Regeneration of rat molar pulp tissue by the implantation of stem cells from incisor pulp: development of a rat model of autologous pulp tissue engineering
-
批准号:26293405
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.4万
-
财政年份:2014
-
负责人:OKIJI Takashi
-
依托单位:
Application of activated macrophages derived from dental pulp stem cells to dental pulp tissue engineering
-
批准号:25670808
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2013
-
负责人:OKIJI Takashi
-
依托单位:
Elucidation of the mechanism of post-repantation replacement resorption as a basis for the development of periodontal ligament regeneration therapy
-
批准号:23659887
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2011
-
负责人:OKIJI Takashi
-
依托单位:
Pathogenic mechanisms in apical periodontitis : innate immunity, acquired immunity and dendritic cell maturation
-
批准号:20390483
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.73万
-
财政年份:2008
-
负责人:OKIJI Takashi
-
依托单位:
Immune defense mechanisms of the dentin/pulp complex: Immunohistochemical analysis on the heterogeneity and kinetics of dendritic cells
-
批准号:17390508
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.18万
-
财政年份:2005
-
负责人:OKIJI Takashi
-
依托单位:
Pathogenic mechanisms of apical periodontal diseases : Kinetics of dendritic cells and immure functional molecules
-
批准号:14370616
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.95万
-
财政年份:2002
-
负责人:OKIJI Takashi
-
依托单位:
Immune defense mechanisms of the dentin/pulp complex. An immunological and molecular biological analysis
-
批准号:11470402
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.86万
-
财政年份:1999
-
负责人:OKIJI Takashi
-
依托单位:
Neuro-immune connection in deseased dental pulp-an immunohistochemical study
-
批准号:07672070
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1995
-
负责人:OKIJI Takashi
-
依托单位:
国内基金
海外基金
登录
查看更多内容
人体组织体外再生装备系统及再生医学材料技术研发
-
批准号:2025QK3007
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:刘海蓉
-
依托单位:
基于间皮细胞亚群异质性的腹膜损伤修复再生医学方法开发及其机制研究
-
批准号:32301150
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2023
-
负责人:王宇嘉
-
依托单位:
一种新型的Wnt通路激动剂及其在再生医学的应用
-
批准号:92068115
-
项目类别:重大研究计划
-
资助金额:78.0万元
-
批准年份:2020
-
负责人:池天
-
依托单位:
骨科生物材料与再生医学
-
批准号:--
-
项目类别:国家杰出青年科学基金
-
资助金额:400万元
-
批准年份:2019
-
负责人:李斌
-
依托单位:
面向2035的我国再生医学创新与产业发展战略研究
-
批准号:--
-
项目类别:专项基金项目
-
资助金额:80万元
-
批准年份:2019
-
负责人:顾晓松
-
依托单位:
利用微流控/纳米技术构建血管/神经网络用于再生医学
-
批准号:81730051
-
项目类别:重点项目
-
资助金额:290.0万元
-
批准年份:2017
-
负责人:蒋兴宇
-
依托单位:
基于微结构的粘性仿生薄膜在软骨和皮肤组织再生医学中的基础研究
-
批准号:31671037
-
项目类别:面上项目
-
资助金额:62.0万元
-
批准年份:2016
-
负责人:康跃军
-
依托单位:
复合siRNA的再生医学材料及其诱导皮肤无瘢痕修复研究
-
批准号:50873088
-
项目类别:面上项目
-
资助金额:32.0万元
-
批准年份:2008
-
负责人:马列
-
依托单位:
具有取向孔结构和梯度活性分布的再生医学材料及其原位诱导组织再生研究
-
批准号:50603022
-
项目类别:青年科学基金项目
-
资助金额:10.0万元
-
批准年份:2006
-
负责人:马列
-
依托单位: