Development of Sequential Metathesis of Cyclobutenecarboxylates and Its Application

烯烃复分解反应是现代有机化学中一种强有力的合成工具。最近，通过将几个复分解步骤组合成多米诺过程，已经开发了新的方法。在这项研究中，我们开发了环丁烯羧酸衍生物的开环/闭环复分解作为一种新的方法，简洁地获得γ-丁烯内酯。并利用该方法实现了生物活性天然产物棒内酯的不对称全合成。

Olefin metathesis is a powerful synthetic tool in modern organic chemistry. Recently, new methods have been developed by combining several metathesis steps into a domino process. In this study, we developed the ring-opening/ring-closing metathesis of cyclobutenecarboxylate derivatives as a novel method for concise access to gamma-butenolides. Furthermore, we achieved the asymmetric total synthesis of the bioactive natural products clavilactones by use of this method.