Electrolytes gradient dependent nutritional absorption.

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Multicellular organism is surrounded by the epithelial cell sheets. Epithelial cell sheet is composed of epithelial cells which are adhered each other by cell-cell adhesion complex. Epithelial cell sheets cover inside and outside of our body and the play a biological specific role as organ like skin, intestine and so on. In this research, I analyzed the tight junction mechanism, by which biologically adequate microenvironment can be formed in our body. In this study, I focused especially on small intestine using clausdin-2 and -15 knockout mice. The claudin-2 and -15 knockout mice showed imbalanced electrolytes of intestine induced malnutrition and infantile death.