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Development of Novel Cancer Immunotherapy Targeting Mutated Genes: Identification of Antigen Epitopes Derived from the Mutated KRAS and EGFR Genes.

Development of Novel Cancer Immunotherapy Targeting Mutated Genes: Identification of Antigen Epitopes Derived from the Mutated KRAS and EGFR Genes.
针对突变基因的新型癌症免疫疗法的开发：从突变的 KRAS 和 EGFR 基因衍生的抗原表位的鉴定。
批准号：
23591913
负责人：
SASADA Tetsuro
金额：
$3.33万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591913/
关键词：
免疫療法突然変異遺伝子T細胞エピトープペプチドワクチン上皮成長因子受容体（EGFR)KRAS上皮成長因子受容体（EGFR）Ｔ細胞エピトープ

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中文摘要
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英文摘要
Personalized cancer treatments targeting oncogenic mutated genes are currently developing. Since mutated genes are recognized as foreign by the host immune system, they might be an appropriate target for cancer immunotherapy. In the current study, we have identified two antigen epitopes derived from the epidermal growth factor receptor (EGFR) T790M mutation, which is known to cause resistance to gefitinib in non-small cell lung cancer, and one antigen epitope derived from the KRAS (G12V) mutation, which is frequently detected in colorectal cancer. Our results could provide a novel immunotherapeutic approach for treatment against refractory advanced cancer patients with these mutations, and might lead to development of "personalized immunotherapy targeting mutated genes".
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会议论文
Predictive Biomarker in Cancer Patients Receiving Personalized Peptide Vaccination.
接受个性化肽疫苗接种的癌症患者的预测生物标志物。
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Sasada T, Matsueda S, Shichijo S, Komatsu N, Noguchi M, Yamada A, Itoh K.]
通讯作者： Itoh K.
EGFR T790M mutation as a possible target for immunotherapy; identification of HLA-A*0201-restricted T cell epitopes derived from the EGFR T790M mutation.
DOI： 10.1371/journal.pone.0078389
发表时间： 2013
期刊： PloS one
影响因子： 3.7
作者： [Yamada T, Azuma K, Muta E, Kim J, Sugawara S, Zhang GL, Matsueda S, Kasama-Kawaguchi Y, Yamashita Y, Yamashita T, Nishio K, Itoh K, Hoshino T, Sasada T]
通讯作者： Sasada T
テーラーメイドがんペプチドワクチン療法
量身定制的癌症肽疫苗疗法
DOI： --
发表时间： 2012
期刊： G.I.Research
影响因子： --
作者： [元井紀子, 石川雄一, 山田亮]
通讯作者： 山田亮
Humoral immune responses to EGFR-derived peptides predict progression-free and overall survival of non-small cell lung cancer patients receiving gefitinib.
DOI： 10.1371/journal.pone.0086667
发表时间： 2014
期刊： PloS one
影响因子： 3.7
作者： [Azuma K, Komatsu N, Hattori S, Matsueda S, Kawahara A, Sasada T, Itoh K, Hoshino T]
通讯作者： Hoshino T
共 16 条
    Idenification of tumor antigens in pancreatic cancer by proteomic analysis.
    • 批准号：
      15591461
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.18万
    • 财政年份：
      2003
    • 负责人：
      SASADA Tetsuro
    • 依托单位：
      The Tazuke Kofukai
    海外基金