Probucol attenuates gentamicin-induced cochlear hair cell loss by inhibition of apoptosis.

普罗布考通过抑制细胞凋亡来减轻庆大霉素诱导的耳蜗毛细胞损失。

• 批准号: 23592474
• 负责人: SAKAMOTO Takashi
• 金额: $ 3.49万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592474/
• 关键词: 内耳有毛細胞; 抗脂血症薬; アポトーシス; プロブコール; 高脂血症薬; 高脂血症治療薬

Probucol is one of the representative lipid-lowering agent with anti-inflammatory and antioxidant properties that has a long history of clinical application for the treatment and prevention of cardiovascular diseases. Recently, several studies have revealed its neuroprotective property. However, to date, protective effect of probucol for cochlear hair cell remains to be elucidated. In the present using cochlear explant culture for 24 h, probucol attenuated hair cell loss and apoptosis induced by 0.3 micro M of gentamicin. Moreover, 100 micro M of probucol was most effective, suggesting that there is an optimal concentration for protective effect. These results revealed the neuroprotective effect of probucol in cochlear hair cells.

普罗布考是具有抗炎和抗氧化作用的代表性降脂药之一，临床应用历史悠久，用于心血管疾病的治疗和预防。最近，一些研究揭示了它的神经保护特性。然而，迄今为止，普罗布考对耳蜗毛细胞的保护作用仍有待阐明。在目前使用耳蜗外植体培养24小时，普罗布考衰减毛细胞损失和0.3 μ M的庆大霉素诱导的细胞凋亡。此外，100 μ M的普罗布考是最有效的，这表明存在保护作用的最佳浓度。这些结果揭示了普罗布考对耳蜗毛细胞的神经保护作用。

项目成果

Current concepts in age-related hearing loss: epidemiology and mechanistic pathways.

• DOI: 10.1016/j.heares.2013.01.021
• 发表时间: 2013-09
• 期刊: Hearing research
• 影响因子: 2.8
• 作者: Yamasoba T;Lin FR;Someya S;Kashio A;Sakamoto T;Kondo K
• 通讯作者: Kondo K

Evaluation of the Internal Structure of Normal and Pathological Guinea Pig Cochleae Using Optical Coherence Tomography

• DOI: 10.1159/000354620
• 发表时间: 2013-01-01
• 期刊: AUDIOLOGY AND NEURO-OTOLOGY
• 影响因子: 1.6
• 作者: Kakigi, Akinobu;Takubo, Yuya;Yamasoba, Tatsuya
• 通讯作者: Yamasoba, Tatsuya

Morphological and functional changes in a new animal model of Meniere's disease

• DOI: 10.1038/labinvest.2013.91
• 发表时间: 2013-09-01
• 期刊: LABORATORY INVESTIGATION
• 影响因子: 5
• 作者: Egami, Naoya;Kakigi, Akinobu;Yamasoba, Tatsuya
• 通讯作者: Yamasoba, Tatsuya

Age-related hearing loss in Mn-SOD heterozygous knockout mice.

• DOI: 10.1155/2013/325702
• 发表时间: 2013
• 期刊: Oxidative medicine and cellular longevity
• 作者: Kinoshita M;Sakamoto T;Kashio A;Shimizu T;Yamasoba T
• 通讯作者: Yamasoba T

外耳道閉鎖症の術後聴力に影響を及ぼす因子に関する多重ロジスティック回帰分析による検討

外耳道闭锁术后听力影响因素的多元Logistic回归分析

• 发表时间: 2011
• 作者: 坂本幸士;樫尾明憲;安井拓也;狩野章太郎;柿木章伸;山岨達也
• 通讯作者: 山岨達也