Construction and analysis of the evaluation system of environmental chemical substances on longevity using a longevity gene as an index of assessment

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To construct a new evaluation system for environmental contaminants, we have examined effects of chemical contaminants on expression of sirtuin family using PC12 cell system. As results, expression of Sirt 1 was significantly up-regulated by treatment of diethyl phthalate (one of the potential endocrine disrupters and enhance element of apoptosis in the cell), copper or hydrogen peroxide in PC12 cells. In addition, the tendency that expression of Sirt1 and Sirt2 was decreased in the rat offspring from undernourished pregnant mothers was observed. From the results, it was concluded that measurement of Sirt1 and Sirt2 were useful tool for evaluation of chemical substances on organism.