Efffects of D-serine on neurophathic pain

甩尾或福尔马林试验表明，D-氨基酸缺陷小鼠痛阈值降低。神经病理性疼痛模型(SNL模型)大鼠前脑(纹状体、海马、皮质)和脊髓中丝氨酸消旋酶和D-氨基酸氧化酶的mRNA和蛋白表达增加。SNL模型大鼠前脑和脊髓D-丝氨酸水平升高。这些结果表明，神经病理性疼痛的SNL模型中D-丝氨酸水平升高至少部分参与了NMDA受体通过甘氨酸部位的激活。

Tail flick or formalin test demonstreated that D-amino acid deficient mice decreased pain threshold. The expressin of mRNA and protein of serine racemase and D-amino acid oxidase increased in forebrain (striatum, hippocampus, cortex) and spinal cord of neuropathic pain model (SNL model). The levels of D-serine increased in forebrain and spinal cord in SNL model. These results demonstrated that elevated D-serine level in SNL model developing neuropathic pain could at least in part be involeved in the activation of NMDA receptor via glycine site.