Control of formation of molecular assembly using artificial hydrophobic cavity in DNA

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We have established a convenient way to construct the molecular assembly of functional dyes within DNA using an artificial hydrophobic pocket created in DNA by replacing nucleotides with abasic site analogs. We also investigated the photochemical properties of the molecular assembly in the complex composed of DNA and the functional dyes. The facially stacked functional dyes in DNA were found to generate a long-lived charge separated state by photo excitation and display photocurrent with high efficiency. We have also developed the fluorescence sensor for the target nucleic acid or metal ions using the unique binding behavior of the hydrophobic fluorescent dyes to the mutation sites in DNA.