Image analysis of proteins and functional RNA related to telomerase

一种由人类端粒酶（hTERT）、核干蛋白（NS）和BRG1组成的新型复合物对肿瘤起始细胞的维持很重要（Okamoto N.等，PNAS, 2011）。我们发现与异染色质形成有关的异染色质蛋白1 （HP1）在有丝分裂阶段与分子在重要结构上共定位。这些结果提示hTERT、NS、brg1和HP1共同形成和维持异染色质，暗示肿瘤启动细胞维持和异染色质形成之间存在分子联系。

A novel complex consists of human telomerase (hTERT), Nucleostemin (NS) and BRG1 is important for the maintenance of tumor initiating cells (Okamoto N., et al., PNAS, 2011). We found that Heterochromatin protein 1 (HP1), which are related to the heterochromatin formation, co-localize with the molecules on the important structure during the mitotic phase. These results suggest that hTERT, NS, BRG1and HP1 collaborate to form and maintain heterochromatin and imply the molecular link between tumor initiating cell maintenance and heterochromatin formation.