Screening of radio-sensitizing phytochemicals and examination on their structures

我们筛选了大约40种黄酮类化合物，以寻找来自植物的新型放射增敏剂。通过筛选，我们发现2种黄酮均能增强癌细胞的放射敏感性，其中一种黄酮A对癌细胞的放射增敏作用强于正常细胞。此外，我们认为细胞凋亡参与了放射致敏。这些结果表明，黄酮类A具有微弱的细胞毒性和对癌细胞的优先放射增敏作用，是一种有效的放射增敏剂。

We performed screening of about 40 kinds of flavonoid to find novel radiosensitizers derived from plants. From the screening, we found that 2 kinds of flavonoid enhance radiosensitivity of cancer cells and one of the flavonoids (Flavonoid A) has a stronger radiosensitization action to cancer cells compared with normal cells. Furthermore, it is suggested that apoptosis contributes to the radiosensitization. These results show that Flavonoid A is an efficacious radiosensitizer because of its faint cytotoxicity and preferential radiosensitization to cancer cells.