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Mechanisms And Possible Novel Treatments for Nocturiarelated to Abnormal Circadian Rhythm

Mechanisms And Possible Novel Treatments for Nocturiarelated to Abnormal Circadian Rhythm
与昼夜节律异常相关的夜尿症的机制和可能的新疗法
批准号:
23659754
负责人:
TAKEDA Masayuki
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
Some of TRP (Transient Receptor Potential)s is thought to be important as mechano-sensitive cation channels in the urinary bladder. Afteractivation of TRPV4 by stretch, ATP is released from the urothelial cells. The mechanisms of ATP production by cell-stretch include a novel small molecule transporter VNUT (Vesicular nucleotide transporter), and the expression level of VNUT correlates with human bladder function. Piezo 1, a novel mechanosensor molecule, is important for urinary bladder function. Knockout mice of Per 2, a clock gene, show disappearance of circadian rhythm.
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Beta-catenin signaling PDGF-elicited bladder smooth muscle cell contraction through upregulation of Cx43 expression
β-连环蛋白信号 PDGF 通过上调 Cx43 表达引起膀胱平滑肌细胞收缩
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Li Kai, Jian Yao , Norifumi Sawada, Tatsuya Miyamoto, Masanori Kitamura, Masayuki Takeda]
通讯作者: Masayuki Takeda
AUA Plenary Session 3. Highlight on Urodynamics/Female Urology
AUA全体会议3. 尿动力学/女性泌尿学亮点
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Suzuki, H., Hashitani H, Masayuki Takeda]
通讯作者: Masayuki Takeda
Connexin43 hemichannel-mediated regulation of connexin43.
Connexin43 半通道介导的 connexin43 调节。
DOI: 10.1371/journal.pone.0058057
发表时间: 2013
期刊: PloS one
影响因子: 3.7
作者: [Li K, Chi Y, Gao K, Yan Q, Matsue H, Takeda M, Kitamura M, Yao J]
通讯作者: Yao J
Reciprocal regulation between proinflammatory cytokine- induced iNOS and connexin43 in bladder smooth muscle cells
膀胱平滑肌细胞中促炎细胞因子诱导的 iNOS 和连接蛋白 43 之间的相互调节
DOI: --
发表时间: 2011
期刊: J Biol Chem
影响因子: 4.8
作者: [Kai Li, Jian Yao, Liye Shi, Norifumi Sawada, Yuan Chi, Qiaojing Yan, Hiroyuki Matsue, Masanori Kitamura, Masayuki Takeda]
通讯作者: Masayuki Takeda
23
    Mechanism of driver mutation positive lung cancer
    • 批准号:
      15K21525
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.5万
    • 财政年份:
      2015
    • 负责人:
      TAKEDA Masayuki
    • 依托单位:
    Studies on lower urinary tract dysfunction pathogenesis by complex systems network and dynamic homeostasis collapse
    • 批准号:
      15H04972
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.65万
    • 财政年份:
      2015
    • 负责人:
      TAKEDA Masayuki
    • 依托单位:
    Research on vesicular type transporter and refractory lower urinary tract dysfunction
    • 批准号:
      26670699
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      TAKEDA Masayuki
    • 依托单位:
    Teaching Materials and Tools for Education of Information Science for Elementary, Junior High and High School Students
    • 批准号:
      23650515
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      TAKEDA Masayuki
    • 依托单位:
    海外基金