Mechanisms And Possible Novel Treatments for Nocturiarelated to Abnormal Circadian Rhythm
Mechanisms And Possible Novel Treatments for Nocturiarelated to Abnormal Circadian Rhythm
批准号:
23659754
负责人:
TAKEDA Masayuki
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Some of TRP (Transient Receptor Potential)s is thought to be important as mechano-sensitive cation channels in the urinary bladder. Afteractivation of TRPV4 by stretch, ATP is released from the urothelial cells. The mechanisms of ATP production by cell-stretch include a novel small molecule transporter VNUT (Vesicular nucleotide transporter), and the expression level of VNUT correlates with human bladder function. Piezo 1, a novel mechanosensor molecule, is important for urinary bladder function. Knockout mice of Per 2, a clock gene, show disappearance of circadian rhythm.
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Beta-catenin signaling PDGF-elicited bladder smooth muscle cell contraction through upregulation of Cx43 expression
β-连环蛋白信号 PDGF 通过上调 Cx43 表达引起膀胱平滑肌细胞收缩
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Li Kai, Jian Yao , Norifumi Sawada, Tatsuya Miyamoto, Masanori Kitamura, Masayuki Takeda]
通讯作者:
Masayuki Takeda
AUA Plenary Session 3. Highlight on Urodynamics/Female Urology
AUA全体会议3. 尿动力学/女性泌尿学亮点
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Suzuki, H., Hashitani H, Masayuki Takeda]
通讯作者:
Masayuki Takeda
Connexin43 hemichannel-mediated regulation of connexin43.
Connexin43 半通道介导的 connexin43 调节。
DOI:
10.1371/journal.pone.0058057
发表时间:
2013
期刊:
PloS one
影响因子:
3.7
作者:
[Li K, Chi Y, Gao K, Yan Q, Matsue H, Takeda M, Kitamura M, Yao J]
通讯作者:
Yao J
Reciprocal regulation between proinflammatory cytokine- induced iNOS and connexin43 in bladder smooth muscle cells
膀胱平滑肌细胞中促炎细胞因子诱导的 iNOS 和连接蛋白 43 之间的相互调节
DOI:
--
发表时间:
2011
期刊:
J Biol Chem
影响因子:
4.8
作者:
[Kai Li, Jian Yao, Liye Shi, Norifumi Sawada, Yuan Chi, Qiaojing Yan, Hiroyuki Matsue, Masanori Kitamura, Masayuki Takeda]
通讯作者:
Masayuki Takeda
なし
没有任何
DOI:
--
发表时间:
2020
期刊:
なし
影响因子:
--
作者:
[佐竹 澄子, 務台理恵子, 高塚綾子, なし]
通讯作者:
なし
共 23 条
Mechanism of driver mutation positive lung cancer
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批准号:15K21525
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2015
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负责人:TAKEDA Masayuki
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依托单位:
Studies on lower urinary tract dysfunction pathogenesis by complex systems network and dynamic homeostasis collapse
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批准号:15H04972
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.65万
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财政年份:2015
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负责人:TAKEDA Masayuki
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依托单位:
Research on vesicular type transporter and refractory lower urinary tract dysfunction
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批准号:26670699
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:TAKEDA Masayuki
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依托单位:
Teaching Materials and Tools for Education of Information Science for Elementary, Junior High and High School Students
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批准号:23650515
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:TAKEDA Masayuki
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依托单位:
Research on the afferent transduction in the lower urinary tract
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批准号:23390381
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.31万
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财政年份:2011
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负责人:TAKEDA Masayuki
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依托单位:
Foundational technology for light-weight XML-DBMS based on very fast compressed data stream processing
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批准号:22300010
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
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财政年份:2010
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负责人:TAKEDA Masayuki
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依托单位:
Reseaarch on the function and development of new therapy for Ion channels in the lower urinary tract
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批准号:20390423
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.65万
-
财政年份:2008
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负责人:TAKEDA Masayuki
-
依托单位:
Key Technology for XML DB in Embedded Device Based on Efficient Compressed Pattern Matching
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批准号:19300008
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.32万
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财政年份:2007
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负责人:TAKEDA Masayuki
-
依托单位:
Development of efficient machine discovery system based on data compression and pattern matching
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批准号:15300049
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2003
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负责人:TAKEDA Masayuki
-
依托单位:
Elucidation on mechanisms of vanilloid and cannabinoid functions in the urogenital afferent neurotransmissions
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批准号:14370508
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2002
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负责人:TAKEDA Masayuki
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依托单位:
RESEARCHES ON THE NOVEL MECHANISMS OF NEUROTRANSMISSION VIA NITRIC OXIEG IN THE SMOOTH MUSCLES OF THE GENITO-URINMY ORGANS.
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批准号:11470334
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:1999
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负责人:TAKEDA Masayuki
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依托单位:
Studies on fast pattern matching algorithms based on text compressions
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批准号:09680343
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.45万
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财政年份:1997
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负责人:TAKEDA Masayuki
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依托单位:
Research on carbon oxide as a neurotransmitter in the smooth muscle of the urogenital organs
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批准号:09470342
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.38万
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财政年份:1997
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负责人:TAKEDA Masayuki
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依托单位:
Research for the presence and activation mechanism of nitric oxide
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批准号:07457368
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.86万
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财政年份:1995
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负责人:TAKEDA Masayuki
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依托单位:
Study on hybrid type urinary tract using autologous mucosal cells
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批准号:03807104
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1991
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负责人:TAKEDA Masayuki
-
依托单位:
海外基金