The comparison of bone regeneration of implanted bonesubstitute to canine artificial alveolar cleft with and without liquid of bone marrow centesis

犬人工牙槽裂植入骨替代物有无骨髓穿刺液的骨再生比较

• 批准号: 23659932
• 负责人: ECHIGO Seishi
• 金额: $ 2.25万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659932/
• 关键词: 骨再生; 骨再生材料; OCP/Collagen; ビーグル犬; 人工的顎裂; 骨髄穿刺液; 播種

The bone regeneration material which is developed in this graduate school of dentistry, it is made of octacalcium phosphate(OCP)and porcine atelocollagen composites (OCP/Col). Implantation of it to bone defect of self-healing impossibility forms bone bridge formation. but, in histological findings, it is the few different from original matrix bone. It was thought that a formed bone gives a disorder on the occasion of tooth movement of orthodontics. So, after making canine artificial alveolar cleft , I compare of bone regeneration of implanted bonesubstitute(OCP/Col)with and without liquid of bone marrow centesis of the dog. The result of this experiment evaluate good bone formation with mixed implant group.

本研究所研制的骨再生材料是以磷酸八钙（OCP）和猪去端胶原复合物（OCP/Col）为主要成分的骨再生材料。将其植入不能自行愈合的骨缺损处形成骨桥。但组织学表现与原始基质骨无明显差异。据认为，一个形成的骨头给一个障碍之际，牙齿运动的正畸。因此，本研究在制作犬人工牙槽突裂后，比较了植入骨替代物（OCP/Col）在有无犬骨髓穿刺液的情况下的骨再生情况。实验结果显示混合种植体组骨形成良好。