study about a novel elucidation of endoplasmic reticulum stress response on ischemia/reperfusion injury and liver regeneration after massive hepatectomy and living donor liver transplantation

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It is important issue to overcome liver failure after extended hepatectomy (Hx) or living donor liver transplantation which is still serious problem. This time, we investigated the involvement of the endoplasmic reticulum stress response on liver regeneration, using 70% Hx model, postoperative liver regeneration model, and 90% Hx model, postoperative liver failure model. In 90% Hx model, mRNA of intrahepatic endoplasmic reticulum stress response related genes were time-dependently up-regulated up to maximum 6 times at 1, 3, 7, 14, 21 days after Hx. In addition, they were strongly expressed since the late phase after postoperative 7 days. In 70% Hx model, they were time-dependently up-regulated up to about 1.5 to 3 times but not strongly expressed in equivalent to liver failure model.