Uncultured Autogenous Adipose-derived Regenerative Cells Promote Bone Formation During Distraction Osteogenesis
Uncultured Autogenous Adipose-derived Regenerative Cells Promote Bone Formation During Distraction Osteogenesis
批准号:
24791529
负责人:
WATANABE Koji
金额:
$1.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The question of this study was whether uncultured adipose-derived regenerative cells(ADRCs), which can easily be isolated from autologous adipose tissue and contain several types of stem and regenerative cells, promote bone formation in distraction osteogenesis. Sixty rats were randomly assigned to 3 groups. Physiological saline (control group), Type I collagen gel, or a mixture of ADRC and Type I collagen gel (ADRC group) was injected into the distracted callus immediately after distraction termination.The bone density of the distracted callus in the ADRC group increased by 46% compared with the control group at 6 weeks after injection. The fracture strength in the ADRC group increased by 66% compared with the control group at 6 weeks after injection. Real-time PCR of the distracted callus from the ADRC group had higher levels of BMP-2, VEGF A, and SDF-1. Cell labeling in the newly formed bone showed the ADRCs differentiated into osseous tissue at 3 weeks after injection.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Taylor Spatial Frameの矯正精度―脛骨変形矯正症例での評価―
泰勒空间框架的矫正精度 - 胫骨畸形矫正案例的评估 -
DOI:
--
发表时间:
2012
期刊:
臨整外
影响因子:
--
作者:
[渡邊孝治, 松原秀憲, 野村一世, 土屋弘行]
通讯作者:
土屋弘行
下肢長管骨感染性および非感染性偽関節に対するヨード担持チタンプレートによる治療
含碘钛板治疗感染性和非感染性下肢长骨假关节
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[渡邊孝治, 松原秀憲, 野村一世, 土屋弘行]
通讯作者:
土屋弘行
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Watanabe K, Matsubara H, Nomura I, Tsuchiya H.]
通讯作者:
Tsuchiya H.
DOI:
10.1007/s11999-014-3608-8
发表时间:
2014-12-01
期刊:
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
影响因子:
4.2
作者:
[Nomura, Issei, Watanabe, Koji, Tsuchiya, Hiroyuki]
通讯作者:
Tsuchiya, Hiroyuki
Adipose-derived regenerative cells promote bone formation on distraction osteogenesis in rats
脂肪来源的再生细胞促进大鼠牵张成骨的骨形成
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[I. Nomura, K. Watanabe, H. Matsubara, K. Hayashi, H. Tsuchiya]
通讯作者:
H. Tsuchiya
共 17 条
Establishment of guideline for early demineralized lesion found in regular checkup at school
-
批准号:15K20607
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$0.92万
-
财政年份:2015
-
负责人:WATANABE Koji
-
依托单位:
Research on the Lancelot-Grail Cycle, French Arthurian Prose Romances
-
批准号:23520398
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:2011
-
负责人:WATANABE Koji
-
依托单位:
Formation of the ancient Roman rhetoric and its development
-
批准号:18320032
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.19万
-
财政年份:2006
-
负责人:WATANABE Koji
-
依托单位:
A Study of Dental Health Education and Practice Utilized Teaching Materials and Teaching Tools
-
批准号:11672042
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:1999
-
负责人:WATANABE Koji
-
依托单位:
Construction of Slope Stability Analysis System which took Physiccal and Chemical Characteristic of the Landslide Clay
-
批准号:09558052
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$7.36万
-
财政年份:1997
-
负责人:WATANABE Koji
-
依托单位:
A Research of Life Styles and Dental Health behaviors in Young Ages
-
批准号:09672101
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.02万
-
财政年份:1997
-
负责人:WATANABE Koji
-
依托单位:
Tolerance promoting cells were derived from infused donor bone marrow cell (DBMC) in dogs treated with fractionated lymphoid irradiation (FLI) and FK506 (FK)
-
批准号:09671246
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1997
-
负责人:WATANABE Koji
-
依托单位:
HOME MANAGEMENT TAKEN INTO CONSIDERATION THE NURSING LEAVE SYSTEM
-
批准号:06680023
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1994
-
负责人:WATANABE Koji
-
依托单位:
Induction of donor specific unresponsiveness by combined treatment with donor bone marrow cell infusion, and FK506 in cadaveric renal allotransplantation.
-
批准号:04670748
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$0.96万
-
财政年份:1992
-
负责人:WATANABE Koji
-
依托单位:
The Development of the Educational Content and the Teaching Method about Coeducational Home Economics Teaching at Senior High School
-
批准号:03680270
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.02万
-
财政年份:1991
-
负责人:WATANABE Koji
-
依托单位:
Development of high efficiency image processing systems matched to the sampling structure of multidimensinal signal space
-
批准号:60460127
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.99万
-
财政年份:1985
-
负责人:WATANABE Koji
-
依托单位:
Immunosuppressive Effects of Total Lymphoid Irradiation on Kidey Transplantation
-
批准号:60570600
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$0.26万
-
财政年份:1985
-
负责人:WATANABE Koji
-
依托单位:
海外基金