Glycomics for identification of rotavirus receptor and development of antiviral agent

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Rotavirus is the major etiology of severe gastroenteritis in infants especially in developing countries. It is indicated that human rotavirus (hRV) recognizes glycans expressed on host cells as the initial step of virus-cell entry. In this study, glycan structures recognized by hRV were studied by the glycan array method, which we previously established. We found that hRV (MO strain) strongly recognizes NeuGc residues and sulfated glycans. These results indicated that NeuGc and sulfated glycans show an important role in human rotavirus infection.