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東アジアに多発する尿路結石の実態と素因

东亚地区尿路结石多发现状及诱发因素

基本信息

批准号：
09041190
负责人：
遠藤仁
金额：
$ 6.14万
依托单位：
Kyorin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

東アジアのメコン川流域には地域多発型の尿路結石症が存在すると言われ、この地域は“Stone belt"(尿路結石多発地帯)とも呼ばれている。この結石症は他の風土病(腎遠位尿細管性酸血症、周期性四肢麻痺、突然死)との関連が疑われているので、結石症のみならず・他の風土病にも考慮しつつ、その成因の追求を目指した。2年目の平成10年度はラオス人民民主共和国でフィールドワークを実施した・遺伝因子と環境因子を考慮して2カ所に拠点を設けた。即ち、メコン川に沿った都市ビエンチャン(VT)のMahosot病院とVTから約500Km離れたXiang Khouang(XK)村のPhonesavanh病院においてのフィールド調査をLaosのMahosot病院副院長Dr.Akkavong Kongsapが中心となり1998年9月〜1999年2月に実施した。調査項目は1998年度の本班会議で作成したものに従い約200人を対象に詳細に行われた。同時に超音波検査による結石の診断で石の存在を確認できた患者と各地区の正常対照者の臨床医学データと尿及び食物の採取を行った。これら試料は日本に空輸されて日本の班員の研究室を中心に分析された。結果の詳細は別添作成(予定)の報告集冊子に委ねるが、腎結石は壮年男性に多く、喫煙者やXKでは土地特有のハーブを煎じた“お薬"の愛用者の方が高頻度羅患しており、結石患者の尿中の修酸が高く、クエン酸が低いという極めて興味深い結果が得られた。その上VTとXKとの差異も認められ、遺伝と環境の両因子の更なる解析による成因の追及に当って重要な糸口を見出すことができた。

Due to the prevalence of multiple urolithiasis in the Sichuan valley, there are some symptoms of multiple urinary tract disease in the Sichuan basin, such as "Stone belt" and "urinary tract disease" in the region. He suffered from endemic disease (urinary tubular acidemia, periodic numbness of the extremities, sudden death). He suspected that he was suffering from acidemia, the disease was suspected to be complicated, and the cause of disease was in pursuit of the target. In the year of 2000, the people's Democratic Republic will pay attention to the application of environmental factors in the people's Democratic Republic in 2010. That is to say, along the border of the city, the Mahosot Hospital (VT), the Mahosot Hospital, the VT Hospital, the 500Km Hospital, the Xiang Khouang (XK) Village, the Phonesavanh Hospital, the Phonesavanh Hospital, the Mahosot Hospital, the Deputy Director of the Dr.Akkavong Kongsap Hospital, the Deputy Director of the Laos Hospital, and the Center for the Development of the Mahosot Hospital, were selected for the period from September 1998 to February 1999. In 1998, there will be about 200 people in this class. At the same time, the ultrasonic examination results showed that there were patients in all areas who had normal care, medical care, urine examination and food collection. Please contact me for the analysis of the research center of the research office of the Japanese staff. Results the results showed that the report set was (intended) that the report set was characterized by high levels of acid in the urine, low levels of acid in the urine, high levels of acid in the urine, low levels of acid in the urine, high levels of acid in the urine of the patients, high levels of acid in the urine of the patients, low levels of acid in the urine, high levels of acid in the urine, low levels of acid, low levels of acid, high levels of acid in the urine of the patients, and so on. The results showed that the results showed that there was a bad taste in the urine of patients with high levels of acid and low levels of acid. On the VT XK, the environmental impact factors are more important to analyze the cause of formation and when it is important to make an analysis of the causes.