Genomics Core

基因组学核心

• 批准号: 10153809
• 负责人: Wolfgang Zacharias
• 金额: $ 37.48万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10153809
• 关键词: Applications Grants; Award; Bioinformatics; Biomedical Research; Centers of Research Excellence; Clinical; Collaborations; Communities; Core Facility; DNA; Data Analyses; Development; Disease; Environment; Equipment; Etiology; Experimental Designs; Floor; Future; Gene Expression Profiling; Genes; Genetic; Genetic Medicine; Genomics; Genotype; Grant; Health Sciences; Health behavior; Healthcare; Human; Human Resources; Individual; Infrastructure; Institution; Kentucky; Laboratory Research; Life; Logistics; Manuscripts; Methods; MicroRNAs; Molecular; Molecular Medicine; Molecular Target; Nucleic Acids; Patients; Pilot Projects; Population; Preparation; RNA; Research; Research Infrastructure; Research Personnel; Sampling; Services; Technology; Training; Translational Research; Universities; Visualization; base; cancer research center director; combat; cost; data acquisition; equipment acquisition; field study; functional genomics; gene product; genetic makeup; genomic data; human disease; innovative technologies; programs; student training; therapy development; transcriptome; transcriptome sequencing; whole genome

GENOMICS CORE Summary: The thematic research focus of the KBRIN program is “functional genomics”. This field of study is relevant to all aspects of life, health, and behavior of humans based on their genetic make-up and interactions with their individual environment. The study of genes, their gene products, and their mutual interactions has become crucial for the development of therapies to combat human diseases, to understand the etiology of such diseases, and to narrow in on personalized individual treatment options based on genetic and genomic information of the patient. Thus, functional genomics technologies like those implemented in the UofL Genomics Core will be increasingly essential for the health care of current and future populations. Innovative technologies like whole genome DNA and transcriptome RNA sequencing and massively parallel gene expression profiling have become technically and economically feasible. However, the infrastructure is best placed in centralized facilities because it is cost-prohibitive for individual research laboratories. Thus, the instrumental and intellectual research infrastructure provided by the Core represents a critical component for the future overall strategic purpose for biomedical research community in Kentucky, with the potential for a positive state-wide impact for the development of competitive research. This core, its equipment and its staff will serve the UofL and its research base, and will also serve the investigators in the network-affiliated institutions in the KBRIN.

基因组学核心 KBRIN项目的主题研究重点是“功能基因组学”。这一领域的 研究涉及人类生活，健康和行为的各个方面，基于其遗传组成， 与个人环境的互动。研究基因、基因产物及其相互作用的科学。 相互作用对于开发治疗人类疾病的疗法至关重要， 这些疾病的病因，并缩小在个性化的个人治疗方案的基础上， 患者的遗传和基因组信息。因此，功能基因组学技术，如 在UofL基因组学核心实施将越来越重要的医疗保健， 未来的人口。 全基因组DNA和转录组RNA测序等创新技术， 平行基因表达谱分析在技术上和经济上已经变得可行。但 基础设施最好放在集中的设施中，因为它对个人研究来说成本过高 laboratories.因此，核心提供的工具和智力研究基础设施代表了 肯塔基州生物医学研究界未来总体战略目标的关键组成部分， 具有对竞争性研究的发展产生积极影响的潜力。这个核心， 设备及其工作人员将为UofL及其研究基地服务，也将为研究人员服务。 KBRIN的网络附属机构。