Genomics Core

基因组学核心 摘要：KBRIN计划的主题研究重点是“功能基因组学”。这一领域 根据人类的基因构成和行为，研究与人类生活、健康和行为的方方面面有关 与他们的个人环境相互作用。对基因、基因产物及其相互作用的研究 相互作用对于抗击人类疾病的治疗方法的开发至关重要，以了解 此类疾病的病因，并根据以下情况缩小个性化治疗方案的范围 患者的遗传和基因组信息。因此，像这样的功能基因组技术 在UofL基因组学核心中实施将对当前和 未来的人口。 全基因组DNA和转录组RNA测序等创新技术 并行基因表达谱分析在技术上和经济上都是可行的。然而， 基础设施最好放在集中化的设施中，因为它对单个研究来说成本高昂 实验室。因此，核心提供的工具和智力研究基础设施代表 肯塔基州生物医学研究社区未来总体战略目标的关键组成部分， 有可能在全州范围内对竞争性研究的发展产生积极影响。这个核心，它的 设备及其工作人员将为加州大学法学院及其研究基地服务，也将为 KBRIN中的网络附属机构。

GENOMICS CORE Summary: The thematic research focus of the KBRIN program is “functional genomics”. This field of study is relevant to all aspects of life, health, and behavior of humans based on their genetic make-up and interactions with their individual environment. The study of genes, their gene products, and their mutual interactions has become crucial for the development of therapies to combat human diseases, to understand the etiology of such diseases, and to narrow in on personalized individual treatment options based on genetic and genomic information of the patient. Thus, functional genomics technologies like those implemented in the UofL Genomics Core will be increasingly essential for the health care of current and future populations. Innovative technologies like whole genome DNA and transcriptome RNA sequencing and massively parallel gene expression profiling have become technically and economically feasible. However, the infrastructure is best placed in centralized facilities because it is cost-prohibitive for individual research laboratories. Thus, the instrumental and intellectual research infrastructure provided by the Core represents a critical component for the future overall strategic purpose for biomedical research community in Kentucky, with the potential for a positive state-wide impact for the development of competitive research. This core, its equipment and its staff will serve the UofL and its research base, and will also serve the investigators in the network-affiliated institutions in the KBRIN.