Genomics Core

十多年前，我们的生物信息学基础设施和能力的发展是肯塔基州两个主要研究机构的新重点，因为他们清楚地认识到与生命科学中“组学”时代的蓬勃发展相关的需求。最近，健康相关和生物医学信息学被视为临床和转化研究的挑战性需求。目前，各区域机构都认识到生物信息学的重要性，因为生物信息学被视为本科理科课程，特别是生物学和计算机科学课程的一项重要要求。我们将继续鼓励我们的KBRIN附属区域机构将生物信息学纳入其研究和教育任务。此外，我们建议将我们的KBRIN外展机构纳入这一“运动”，使国家的本科学生的更大比例可以在我们的整体综合基因组学/生物信息学研究培训/教育使命从事。 我们的生物信息学运作模式（表10）显示，我们的6个KBRIN主要网络机构中的每一个都有资源致力于生物信息学的某些方面，无论是在研究，培训还是教育方面。例如，Uofils致力于消除目前阻碍研究进展的数据分析管道中的瓶颈。同样，英国正在开发一个临床转化科学奖（CTSA）支持的生物信息学中心，以支持翻译/临床研究。在我们的网络中，生物信息学基础设施最令人印象深刻的发展是50个成员的强大 生物信息学和信息科学中心（BISC）。将跨部门的生物信息学整合到一个区域机构的类似中心的组织中必须是第一次。与该中心相关的两名教师多年来一直参与HHMI的SEA-PHAGE计划，这是向本科生介绍基因组学/生物信息学研究培训/教育的独特工具。我们打算利用他们的经验和专业知识，以及两所研究密集型大学的核心设施和资源，在我们的外展机构中建立以KBRIN为中心的基因组学/生物信息学培训活动。这将使我们的功能基因组学主题扩大网络的本科生（见行政核心）。生物信息学核心叙述在以下标题下描述： (1)基础设施，（2）研究，（3）教育和培训，（4）未来五年。 (1)基础设施：在Uofl，我们最初遇到的一个主要问题是在多个校区的跨学科/多学科研究人员之间建立兴趣和合作。这些包括解剖科学和神经生物学，生物化学和。分子生物学，生物信息学和生物统计学，在健康科学校园和化学，计算机工程和计算机科学，生物学，心理学和数学在主/本科校园，地理上相隔几英里。为了加强这些研究人员之间的合作，并让更多的生物医学研究人员参与生物信息学，PI与EVPRI和医学院院长进行了谈判，在过去的5年资助周期内，在路易斯维尔大学的健康科学校园（图20）开发了一个专用的1900平方英尺的空间和一个最先进的视频会议设施。 这个空间是完全可操作的，并允许KBRIN进一步发展生物信息学研究能力，并提供一个机制，保持与整个校园和整个国家的生物信息学研究人员的密切联系。它目前由KBRIN附属的研究人员居住，并可以容纳来自其他校园和/或KBRIN机构的访问教师。我们希望随着额外的需求和资源的可用而扩大这个空间。

Over a decade ago, the development of our bioinformatics infrastructure and capabilities was a new focus for the 2 major research institutions in KY because they had clearly recognizable needs associated with the blossoming of the 'omics' era in the life sciences. More recently, health-related and biomedical informatics are seen as challenging necessities for clinical and translational research. The recognition of the importance of bioinformatics is being expressed now in the regional institutions, because bioinformatics is seen to be an important requirement in the undergraduate science curriculum, especially in biology and computer science classes. We will continue to encourage our KBRIN-affiliated regional institutions to integrate bioinformatics into their research and educational missions. In addition, we propose to incorporate our KBRIN-outreach institutions into this 'movement' so that a larger proportion of the state's undergraduate student body can be engaged in our overall integrated genomics/bioinformatics research training/education mission. Our operational model for bioinformatics (Table 10, above) shows that each of our 6 KBRIN primary networked institutions have resources committed to some aspect of bioinformatics whether it be in research, training or education. For example, Uofils committed to eliminating the bottlenecks in the data-analyses pipeline that currently hold up progress in research. UK, similarly, is developing a Clinical Translational Science Award (CTSA) supported bioinformatics center in support of translation/clinical research. A most impressive development in bioinformatics infrastructure among our network has to be the 50 member strong Bioinformatics and Information Science Center (BISC) at WKU. The integration of bioinformatics across departments into a Center-like organization at a regional institution has to be a first. Two faculty members associated with this center have participated for several years in the HHMI's SEA-PHAGE program, a unique vehicle for introducing genomics/bioinformatics research training/education to undergraduate students. We intend to make use of their experience and expertise, together with the core facilities and resources at the 2 research intensive universities to establish a KBRIN-centric genomics/bioinformatics training exercise in our outreach institutions. This will bring our functional genomics theme to an expanded network of undergraduate students (see administrative core). The bioinformatics core narrative is described under the following headings: (1) Infrastructure, (2) Research, (3) Education and Training (4) The Next Five Years. (1) Infrastructure: At Uofl we initially had a major problem building interest and collaborations between interdisciplinary/multi-disciplinary investigators on multiple campuses. These include investigators in Anatomical Science and Neurobiology, Biochemistry and. Molecular Biology, Bioinformatics and Biostatistics, on the Health Sciences campus and Chemistry, Computer Engineering and Computer Science, Biology, Psychology and Mathematics on the main/undergraduate campus, geographically separated by several miles. To enhance collaboration between these researchers, and engage more biomedical researchers a bioinformatics, the PI negotiated with the EVPRI and the Dean oUhe School of Medicine to develop a dedicated 1900 ft2 space and a state-of-the-art videoconferencing facility on the University of Louisville's Health Science Campus (Figure 20) in this past 5 year funding cycle. This space is fully operational and allows for KBRIN to further develop bioinformatics research capability and provide a mechanism for keeping close contact with bioinformatics researchers across campus and throughout the state. It is currently inhabited by KBRIN-affiliated researchers, and can accommodate visiting faculty from other campuses and/or KBRIN institutions. We hope to grow this space as additional needs and resources become available.