Data Science COre

数据科学核心：摘要 数据科学核心(DSC)的目的是提供生物统计学、生物信息学方面的专业知识 和所有SARS-CoV-2血清学英才中心(U54)项目的研究信息学， 调查人员和参与者。该核心提供的功能包括开发实验设计和 能力和样本量分析；数据库开发、数据质量控制；统计和生物信息学分析 和对调查结果的解释；以及在提出结果方面的合作。为了实现这些功能，核心 中心主任余雪博士和核心成员林恩·贝瑞博士、刘奇博士和伊曼纽拉·泰奥利博士经常与 调查人员，并与项目和核心领导保持定期联系。 DSC的主要目标是： 1.提供研究设计并审查所有实验室、动物和翻译研究，包括可行性 评估、能力和样本量分析。 2.在项目数据分析、结果解释和撰写最终研究报告方面进行合作 手稿。 3.与临床研究中心合作开发研究项目数据库，以维持数据质量控制 并确保及时捕获数据。 4.开发和评价用于实验设计和数据分析的统计/生物信息学方法。 所有U54研究都需要DSC支持。核心人员已经并将继续与 项目负责人确保核心提供最先进的统计、生物信息和研究信息 根据需要提供支持。

DATA SCIENCE CORE: ABSTRACT The purpose of the Data Science Core (DSC) is to provide professional expertise in biostatistics, bioinformatics and research informatics for all SARS-CoV-2 Serological Sciences Centers of Excellence (U54) projects, investigators and participants. Functions provided by this core include development of experimental designs and power and sample size analysis; database development, data quality control; statistical and bioinformatic analysis and interpretation of findings; and collaboration on presentation of results. To achieve these functions, the core director, Dr Yu Shyr, and core members, Drs. Lynne Berry, Qi Liu and Emanuela Taioli, are constantly available to investigators and are in regular contact with project and core leaders. The primary objectives of the DSC are: 1. To provide study design and review all laboratory, animal and translational studies including feasibility assessment, power and sample size analysis. 2. To collaborate in project data analysis, interpretation of results and the writing of final study reports and manuscripts. 3. To work with the Clinical Core in the development of research project databases to maintain data quality control and to ensure timely data capture. 4. To develop and evaluate statistical/bioinformatic methods for experimental design and data analysis. DSC support is required in all U54 studies. Core personnel have worked and will continue to work closely with project leaders to ensure the core provides state-of-the-art statistical, bioinformatic and research informatic support as needed.