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Core 2: Biostatistics Shared Resource Core

核心2：生物统计学共享资源核心

基本信息

批准号：
10328041
负责人：
Yu Shyr
金额：
$ 19.53万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-21 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10328041
关键词：
Address Bioinformatics Bioinformatics Shared Resource Biological Biometry Biostatistics Shared Resource Cancer Center Clinical Clinical Trials Collaborations Computer software Consultations Data Analyses Development Educational workshop Ensure Experimental Designs Funding Human Resources Individual Information Storage Laboratory Study Maintenance Malignant Neoplasms Manuscripts Methodology Methods Participant Pilot Projects Publications Quality Control Questionnaire Designs Reporting Research Research Design Research Personnel Retrieval Role Sample Size Services Statistical Data Interpretation Tennessee The Vanderbilt-Ingram Cancer Center at the Vanderbilt University Training Universities Work Writing cancer health disparity data cleaning data quality data visualization database design design experimental study investigator training medical schools member multidimensional data posters power analysis relational database symposium

项目摘要

PROJECT SUMMARY: BIOSTATISTICS AND BIOINFORMATICS SHARED RESOURCE CORE In this application, we propose to intensify the role of our existing Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) Biostatistics and Bioinformatics Shared Resource Core (BBSRC). The BBSRC will support the proposed two full projects and one pilot project; detailed and specific biostatistical and bioinformatic analysis plans are provided for each specific aim/sub-aim within each project. Sample size for each primary experiment is computed to provide high power to detect clinically or biologically relevant effects. For projects with high-dimensional data analyses, the methods described in the Research Strategy will be applied to assess data quality and then perform statistical analysis only after preprocessing to address quality issues. BBSRC support is required for all MVTCP studies, with biostatisticians and bioinformaticians from this core assigned to each project. BBSRC personnel have worked and will continue to work closely with project leaders to ensure the Biostatistics and Bioinformatics Shared Resource Core provides state-of-the-art statistical/bioinformatic support to the MVTCP.

项目概要：生物统计学和生物信息学共享资源核心在这项申请中，我们建议加强我们现有的梅哈里医学院/范德比尔特-英格拉姆的作用癌症中心/田纳西州立大学癌症伙伴关系（MVTCP）生物统计学和生物信息学共享资源核心（BBSRC）。BBSRC将支持拟议的两个全面项目和一个试点项目; 为每个具体目标/子目标提供详细和具体的生物统计学和生物信息学分析计划在每个项目中。计算每个主要实验的样本量，以提供高功效检测临床或生物学相关效应。对于具有高维数据分析的项目，将应用研究策略中的方法评估数据质量，然后仅在预处理以解决质量问题。所有MVTCP研究都需要生物统计学家的BBSRC支持和生物信息学家从这个核心分配到每个项目。BBSRC的工作人员一直在工作，并将继续与项目负责人密切合作，确保生物统计学和生物信息学共享资源核心为MVTCP提供最先进的统计/生物信息学支持。