Core 3: Biostatistics and Bioinformatics

项目摘要/摘要：生物统计学和生物信息学核心 生物统计和生物信息学核心(BBC)的目的是在以下方面提供专业知识 胃肠癌范德比尔特-英格拉姆癌症中心所有孢子的生物统计和生物信息学 项目、调查人员和参与者。该核心提供的功能包括开发实验 设计、能量分析和样本量估计、数据质量控制、统计/生物信息学分析和 对调查结果的解释，以及在提出结果方面的合作。为了实现这些功能，核心 主任和核心成员经常与调查人员联系，关键的生物统计学家和 分配给每个项目的生物信息学家，所有人都与项目和核心领导保持定期联系。 BBC的主要目标是： 1.提供研究设计并审查所有实验室、动物、翻译、流行病学和临床研究 研究包括可行性评估、能量分析和样本量估计； 2.合作进行项目数据分析，包括生物信息前处理分析、解释 结果，以及最后研究报告和手稿的撰写； 3.与组织病理学和细胞分析核心以及小鼠和人类分子成像合作 核心在开发研究项目数据库，以维护数据质量控制并确保 及时捕获数据； 4.开发和评价用于实验设计和数据分析的统计/生物信息学方法。 所有VICC GI癌症孢子研究都需要BBC的支持，生物统计学家和生物信息学家 分配给每个项目。核心人员已经并将继续与项目负责人密切合作，以 确保核心提供最先进的统计/生物信息支持。

PROJECT SUMMARY/ABSTRACT: Biostatistics and Bioinformatics Core The purpose of the Biostatistics and Bioinformatics Core (BBC) is to provide professional expertise in biostatistics and bioinformatics for all Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal (GI) Cancer projects, investigators, and participants. Functions provided by this core include development of experimental designs, power analysis and sample size estimation, data quality control, statistical/bioinformatics analysis and interpretation of findings, and collaboration on presentation of results. To achieve these functions, the core director and core members are constantly available to investigators, with key biostatisticians and bioinformaticians assigned to each project, and all are in regular contact with the project and core leaders. The primary objectives of the BBC are: 1. To provide study design and review all laboratory, animal, translational, epidemiological, and clinical studies including feasibility assessment, power analysis, and sample size estimation; 2. To collaborate in project data analysis including bioinformatic pre-processing analysis, interpretation of results, and the writing of final study reports and manuscripts; 3. To work with the Tissue Pathology and Cellular Analysis Core and Mouse and Human Molecular Imaging Core in the development of research project databases, to maintain data quality control and to ensure timely data capture; 4. To develop and evaluate statistical/bioinformatic methods for experimental design and data analysis. BBC support is required in all VICC GI Cancer SPORE studies, with biostatisticians and bioinformaticians assigned to each project. Core personnel have worked and will continue to work closely with project leaders to ensure the core provides state-of-the-art statistical /bioinformatic support.