Barrett's Esophagus Translational Research Network Coordinating Center (BETRNetCC)

项目摘要 虽然食管腺癌（EAC）是一种相对罕见的癌症，但这种疾病的发病率 在最近几十年中迅速增加;此外，在检测EA时，大多数患者具有非常 预后不良。在过去的几十年里，EA的惊人增长，沿着的是预后不良， 受影响的人，要求调查这种疾病的危险因素，改善对病人的管理， 风险，并制定预防措施。这些领域的进步将对公共卫生产生重大影响。 在降低受影响者的发病率和死亡率以及减少公共卫生方面， 与高级阶段EA管理相关的成本。 为了更好地管理有EA风险的患者，需要更好地理解 食管肿瘤进展。这种进展涉及巴雷特食管的发展， 一种癌前病变，其中远端食管的正常复层鳞状上皮被替换 柱状上皮，内窥镜检查可见异常，活检证实为特化 柱状上皮伴肠上皮化生。 出于这些原因，NCI开发了巴雷特食管转化研究网络 （BETRNet），这是一个联盟研究计划，目标是减少 EAC通过回答与这种疾病进展相关的关键问题，特别是在 癌前阶段的BE，唯一的前驱病变明确相关的EA。 在这个应用程序中，我们描述了迄今为止的成就，以及对BETRNet的展望 协调中心（BETRNet-CC），具有以下关键职能： ·为BETRNet计划提供行政和后勤支持，包括有效的通信， 协调连接可用资源的工作，作为数据管理中心，并集成 研究中心的活动; ·通过领导和管理不同的团队来协调跨网络研究，以及 为BETRNet的管理机构（指导委员会）提供后勤和行政支持 委员会）;及 ·持续开发、维护和管理BETRNet患者注册表， 生物储存库（BETRNet PR-VB）。

PROJECT SUMMARY Although esophageal adenocarcinoma (EAC) is a relatively uncommon cancer, the incidence of this disease has increased rapidly in recent decades; moreover, at the time of detection of EA, most patients have very poor prognosis. The alarming increase in EA over the past several decades, along with the poor prognosis for those affected, demand investigation into the risk factors for this disease, improved management of patients at risk, and development of preventive measures. Advances in these areas will have significant public health benefit in terms of reducing morbidity and mortality for those affected, as well as reducing the public health costs associated with managing EA at advanced stages. To better manage patients at risk for EA will require an improved understanding of the mechanisms of neoplastic progression in the esophagus. Such progression involves the development of Barrett's esophagus, a premalignant lesion in which the normal stratified squamous epithelium of the distal esophagus is replaced by columnar epithelium, visible as an abnormality on endoscopy, and confirmed on biopsy as specialized columnar epithelium with intestinal metaplasia. For these reasons, the NCI has developed the Barrett's Esophagus Translational Research Network (BETRNet), a consortium research initiative with the goal of reducing the incidence, morbidity, and mortality of EAC, through answering key questions related to the progression of this disease, especially in the premalignant stage of BE, the only precursor lesion definitively associated with EA. In this application we describe the accomplishments to date, as well as the vision forward, for the BETRNet Coordinating Center (BETRNet-CC), with the following critical functions: • Administrative and logistical support for the BETRNet program, including efficient communications and coordination of efforts to connect available resources, serve as a data management center, and integrate activities of the research centers; • Coordination of cross-network research through leadership and management of diverse teams, as well as providing logistical and administrative support to the governing body of the BETRNet (the Steering Committee); and • Ongoing development, maintenance, and administration of the BETRNet patient registry with virtual biorepository (BETRNet PR-VB).