Barrett's Esophagus Translational Research Network Coordinating Center (BETRNetCC)

巴雷特食管转化研究网络协调中心 (BETRNetCC)

• 批准号: 9883629
• 负责人: Yu Shyr
• 金额: $ 39.08万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9883629
• 关键词: Affect; Area; Barrett Esophagus; Biopsy; Clinical; Collaborations; Columnar Epithelium; Communication; Communication Tools; Data; Data Collection; Detection; Development; Disease; Disease Progression; Distal; Endoscopy; Esophageal Adenocarcinoma; Esophagus; Goals; Group Meetings; Health Benefit; Health Care Costs; Incidence; Informed Consent; Intestinal Metaplasia; Investigation; Leadership; Lesion; Logistics; Maintenance; Malignant Neoplasms; Monitor; Morbidity - disease rate; Outcome; Patient-Focused Outcomes; Patients; Periodicity; Persons; Pilot Projects; Play; Preventive measure; Process; Public Health; Reporting; Research; Research Activity; Resources; Risk; Risk Factors; Specimen; Stratified Squamous Epithelium; Time; Translational Research; Vision; biobank; data management; improved; meetings; mortality; outcome forecast; patient registry; premalignant; programs; success; symposium; tumor progression; virtual; web portal; working group

PROJECT SUMMARY Although esophageal adenocarcinoma (EAC) is a relatively uncommon cancer, the incidence of this disease has increased rapidly in recent decades; moreover, at the time of detection of EA, most patients have very poor prognosis. The alarming increase in EA over the past several decades, along with the poor prognosis for those affected, demand investigation into the risk factors for this disease, improved management of patients at risk, and development of preventive measures. Advances in these areas will have significant public health benefit in terms of reducing morbidity and mortality for those affected, as well as reducing the public health costs associated with managing EA at advanced stages. To better manage patients at risk for EA will require an improved understanding of the mechanisms of neoplastic progression in the esophagus. Such progression involves the development of Barrett's esophagus, a premalignant lesion in which the normal stratified squamous epithelium of the distal esophagus is replaced by columnar epithelium, visible as an abnormality on endoscopy, and confirmed on biopsy as specialized columnar epithelium with intestinal metaplasia. For these reasons, the NCI has developed the Barrett's Esophagus Translational Research Network (BETRNet), a consortium research initiative with the goal of reducing the incidence, morbidity, and mortality of EAC, through answering key questions related to the progression of this disease, especially in the premalignant stage of BE, the only precursor lesion definitively associated with EA. In this application we describe the accomplishments to date, as well as the vision forward, for the BETRNet Coordinating Center (BETRNet-CC), with the following critical functions: • Administrative and logistical support for the BETRNet program, including efficient communications and coordination of efforts to connect available resources, serve as a data management center, and integrate activities of the research centers; • Coordination of cross-network research through leadership and management of diverse teams, as well as providing logistical and administrative support to the governing body of the BETRNet (the Steering Committee); and • Ongoing development, maintenance, and administration of the BETRNet patient registry with virtual biorepository (BETRNet PR-VB).

项目总结 虽然食管腺癌(EAC)是一种相对少见的癌症，但这种疾病的发病率 近几十年来迅速增加；而且，在检测到EA时，大多数患者都非常 预后不良。在过去的几十年里，EA的增长令人震惊，同时预后不佳 那些受影响的人，要求调查这种疾病的风险因素，改善对患者的管理 风险，以及制定预防措施。这些领域的进步将对公共卫生产生重大影响 在减少受影响者的发病率和死亡率以及减少公共健康方面受益 与高级阶段的EA管理相关的成本。 为了更好地管理有电针风险的患者，需要更好地理解电针的机制 食道内的肿瘤进展。这种进展涉及巴雷特食道的发展， 食道远端正常复层鳞状上皮被替换的癌前病变 柱状上皮，内窥镜下可见异常，活检证实为特化。 肠化生的柱状上皮。 出于这些原因，NCI开发了巴雷特食道翻译研究网络 (BETRNet)，这是一个联盟研究倡议，目的是减少糖尿病的发病率、发病率和死亡率 EAC通过回答与这种疾病发展有关的关键问题，特别是在 癌前阶段的BE，唯一与EA明确相关的前驱病变。 在本应用程序中，我们描述了BETRNet到目前为止的成就以及未来的愿景 协调中心(BETRNet-CC)，具有以下关键职能： ·为BETRNet方案提供行政和后勤支助，包括有效的通信和 协调工作，以连接可用资源，充当数据管理中心，并集成 研究中心的活动； ·通过领导和管理不同的团队以及 向BETRNet管理机构(指导机构)提供后勤和行政支助 委员会)；及 ·BETRNet患者登记簿的持续开发、维护和管理，以及虚拟 生物库(BETRNet PR-VB)。